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学科主题基础医学
Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated
Sun, RQ; Wang, HC; Wan, Y; Jing, Z; Luo, F; Han, JS; Wang, Y
关键词peripheral electrical stimulation neuropathic pain ongoing pain N-methyl-D-aspartate (NMDA) receptor opioid receptor analgesia
刊名EXPERIMENTAL NEUROLOGY
2004-05-01
DOI10.1016/j.expneurol.2003.12.011
187期:1页:23-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SPINOTHALAMIC TRACT NEURONS ; LONG-TERM POTENTIATION ; DORSAL-HORN ; NERVE-STIMULATION ; SPINAL-CORD ; NOCICEPTIVE BEHAVIORS ; INTRADERMAL INJECTION ; FREQUENCY TENS ; MODEL ; INJURY
英文摘要

Peripheral electrical stimulation (PES) has been utilized to manage chronic pain associated with nerve injury. However, the data on clinical effectiveness are conflicting and the neurophysiological mechanism is not well known. This study was designed to assess whether PES relieved neuropathic pain and its possible mechanisms. The neuropathic pain model was made with lumbar 5th (L5) and 6th (L6) spinal nerve ligations in rats. Nociceptive responses of the rats were assessed by the cold plate test (the number and duration of paw lifts that occurred in 5 min on a 5 +/- 1 degreesC cold plate). PES with a frequency of 2 Hz and at increasing strengths was given for 30 min via stainless-steel needles inserted into standard acupoints on the leg and back, respectively. Immunochemistry was used to examine the immunoreactivity of the NMDA receptor 1 (NR1) subunit in the spinal cord dorsal horn. The results are as follows: (1) PES relieved neuropathic pain and the effect was blocked by 1.0 mg/kg naloxone. (2) The effect of one session of PES lasted up to 12 h. (3) Repetitive PES showed a cumulative effect and no tolerance was observed. (4) There was a significant increase of NR1 immunoreactivity ill the superficial laminae of the spinal cord of neuropathic pain rats as compared with naive rats. This increase could be reversed by repetitive 2 Hz PES. These results suggest that PES can relieve neuropathic pain, and that p-opioid receptors and NMDA receptors are involved in the effect of PES. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000220892200003
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53709
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Minist Educ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
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GB/T 7714
Sun, RQ,Wang, HC,Wan, Y,et al. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated[J]. EXPERIMENTAL NEUROLOGY,2004,187(1):23-29.
APA Sun, RQ.,Wang, HC.,Wan, Y.,Jing, Z.,Luo, F.,...&Wang, Y.(2004).Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated.EXPERIMENTAL NEUROLOGY,187(1),23-29.
MLA Sun, RQ,et al."Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated".EXPERIMENTAL NEUROLOGY 187.1(2004):23-29.
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