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学科主题: 基础医学
题名:
Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated
作者: Sun, RQ; Wang, HC; Wan, Y; Jing, Z; Luo, F; Han, JS; Wang, Y
关键词: peripheral electrical stimulation ; neuropathic pain ; ongoing pain ; N-methyl-D-aspartate (NMDA) receptor ; opioid receptor ; analgesia
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2004-05-01
DOI: 10.1016/j.expneurol.2003.12.011
卷: 187, 期:1, 页:23-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SPINOTHALAMIC TRACT NEURONS ; LONG-TERM POTENTIATION ; DORSAL-HORN ; NERVE-STIMULATION ; SPINAL-CORD ; NOCICEPTIVE BEHAVIORS ; INTRADERMAL INJECTION ; FREQUENCY TENS ; MODEL ; INJURY
英文摘要:

Peripheral electrical stimulation (PES) has been utilized to manage chronic pain associated with nerve injury. However, the data on clinical effectiveness are conflicting and the neurophysiological mechanism is not well known. This study was designed to assess whether PES relieved neuropathic pain and its possible mechanisms. The neuropathic pain model was made with lumbar 5th (L5) and 6th (L6) spinal nerve ligations in rats. Nociceptive responses of the rats were assessed by the cold plate test (the number and duration of paw lifts that occurred in 5 min on a 5 +/- 1 degreesC cold plate). PES with a frequency of 2 Hz and at increasing strengths was given for 30 min via stainless-steel needles inserted into standard acupoints on the leg and back, respectively. Immunochemistry was used to examine the immunoreactivity of the NMDA receptor 1 (NR1) subunit in the spinal cord dorsal horn. The results are as follows: (1) PES relieved neuropathic pain and the effect was blocked by 1.0 mg/kg naloxone. (2) The effect of one session of PES lasted up to 12 h. (3) Repetitive PES showed a cumulative effect and no tolerance was observed. (4) There was a significant increase of NR1 immunoreactivity ill the superficial laminae of the spinal cord of neuropathic pain rats as compared with naive rats. This increase could be reversed by repetitive 2 Hz PES. These results suggest that PES can relieve neuropathic pain, and that p-opioid receptors and NMDA receptors are involved in the effect of PES. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000220892200003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53709
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Minist Educ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China

Recommended Citation:
Sun, RQ,Wang, HC,Wan, Y,et al. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated[J]. EXPERIMENTAL NEUROLOGY,2004,187(1):23-29.
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