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学科主题: 临床医学
题名:
Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis
作者: Tian, Meng-Meng; Sun, Yu; Li, Zhong-Wu; Wu, Ying; Zhao, Ai-Lian; Li, Ji-You
关键词: Intercellular adhesion molecule-1 ; Gene polymorphism ; Gastric cancer ; Risk ; Prognosis
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-01-28
DOI: 10.3748/wjg.v18.i4.368
卷: 18, 期:4, 页:368-374
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTERCELLULAR-ADHESION MOLECULE-1 ; BREAST-CANCER ; CLINICAL-SIGNIFICANCE ; HELICOBACTER-PYLORI ; GENE POLYMORPHISMS ; CHINESE POPULATION ; COLORECTAL-CANCER ; SERUM-LEVELS ; E-SELECTIN ; EXPRESSION
英文摘要:

AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in intercellular adhesion molecule-1 (ICAM-1) and the risk, biological behavior and prognosis of gastric cancer (GC) in Chinese population.

METHODS: The study group consisted of 332 GC patients and 380 healthy controls. Genotyping was performed using polymerase chain reaction and the results were confirmed by sequencing. The association of ICAM-1 K469E polymorphisms and the risk of GC were studied, and the correlation of ICAM-1 K469E polymorphisms with the clinicopathological parameters and prognosis of the patients with complete clinical and follow-up data was analyzed.

RESULTS: Carriers of M genotype had a significantly increased risk of GC compared with carriers of AG and GG genotypes [odds ratios: 1.36; 95% confidence interval (CI): 1.01-1.84; P = 0.041]. GC patients with AA genotype were more prone to distant metastasis than those carrying AG and GG genotypes (18.9% vs 7.0%, respectively; P = 0.002). In addition, patients at stage IV had significantly more carriers of AA genotype than those of AG and GG genotype (27.4% vs 16.9%, respectively; P = 0.046). Follow-up study showed that the overall cumulative survival rate was 23.7% in AA genotype group and 42.9% in AG and GG genotypes group. In univariate analysis, AA genotype was correlated with the overall cumulative survival (P = 0.034). But in multivariate analysis, ICAM-1 polymorphism was not an independent prognostic factor for the overall survival (relative risk, 1.145; 95% CI: 0.851-1.540; P = 0.370).

CONCLUSION: Polymorphisms of ICAM-1 K469E can be a useful biomarker for identifying individuals with higher risk of GC, predicting disease progression, and guiding individualized treatment. (C) 2012 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2009BG-02 ; 2006AA02A402 ; 2004CB518702
项目资助者: Beijing Municipal Science and Technology Commission NOVA ; National High Technology Research and Development Program of China ; Major State Basic Research Program of China
WOS记录号: WOS:000299965100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53714
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Dept Pathol, Beijing 100142, Peoples R China

Recommended Citation:
Tian, Meng-Meng,Sun, Yu,Li, Zhong-Wu,et al. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(4):368-374.
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