|Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis|
|Tian, Meng-Meng; Sun, Yu; Li, Zhong-Wu; Wu, Ying; Zhao, Ai-Lian; Li, Ji-You|
|关键词||Intercellular Adhesion Molecule-1 Gene Polymorphism Gastric Cancer Risk Prognosis|
|刊名||WORLD JOURNAL OF GASTROENTEROLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||INTERCELLULAR-ADHESION MOLECULE-1 ; BREAST-CANCER ; CLINICAL-SIGNIFICANCE ; HELICOBACTER-PYLORI ; GENE POLYMORPHISMS ; CHINESE POPULATION ; COLORECTAL-CANCER ; SERUM-LEVELS ; E-SELECTIN ; EXPRESSION|
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in intercellular adhesion molecule-1 (ICAM-1) and the risk, biological behavior and prognosis of gastric cancer (GC) in Chinese population.
METHODS: The study group consisted of 332 GC patients and 380 healthy controls. Genotyping was performed using polymerase chain reaction and the results were confirmed by sequencing. The association of ICAM-1 K469E polymorphisms and the risk of GC were studied, and the correlation of ICAM-1 K469E polymorphisms with the clinicopathological parameters and prognosis of the patients with complete clinical and follow-up data was analyzed.
RESULTS: Carriers of M genotype had a significantly increased risk of GC compared with carriers of AG and GG genotypes [odds ratios: 1.36; 95% confidence interval (CI): 1.01-1.84; P = 0.041]. GC patients with AA genotype were more prone to distant metastasis than those carrying AG and GG genotypes (18.9% vs 7.0%, respectively; P = 0.002). In addition, patients at stage IV had significantly more carriers of AA genotype than those of AG and GG genotype (27.4% vs 16.9%, respectively; P = 0.046). Follow-up study showed that the overall cumulative survival rate was 23.7% in AA genotype group and 42.9% in AG and GG genotypes group. In univariate analysis, AA genotype was correlated with the overall cumulative survival (P = 0.034). But in multivariate analysis, ICAM-1 polymorphism was not an independent prognostic factor for the overall survival (relative risk, 1.145; 95% CI: 0.851-1.540; P = 0.370).
CONCLUSION: Polymorphisms of ICAM-1 K469E can be a useful biomarker for identifying individuals with higher risk of GC, predicting disease progression, and guiding individualized treatment. (C) 2012 Baishideng. All rights reserved.
|项目编号||2009BG-02 ; 2006AA02A402 ; 2004CB518702|
|资助机构||Beijing Municipal Science and Technology Commission NOVA ; National High Technology Research and Development Program of China ; Major State Basic Research Program of China|
|作者单位||Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Dept Pathol, Beijing 100142, Peoples R China|
|Tian, Meng-Meng,Sun, Yu,Li, Zhong-Wu,et al. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(4):368-374.|
|APA||Tian, Meng-Meng,Sun, Yu,Li, Zhong-Wu,Wu, Ying,Zhao, Ai-Lian,&Li, Ji-You.(2012).Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis.WORLD JOURNAL OF GASTROENTEROLOGY,18(4),368-374.|
|MLA||Tian, Meng-Meng,et al."Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis".WORLD JOURNAL OF GASTROENTEROLOGY 18.4(2012):368-374.|