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Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies
Yang, TZ; Zhang, Q; Chen, DB; Nagai, T
关键词Buccal Delivery Absorption Enhancers Insulin Permeability Coefficient Relative Pharmacological Bioavailability
刊名STP PHARMA SCIENCES
2001-11-01
11期:6页:415-419
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]KERATINIZED ORAL-MUCOSA ; HAMSTER-CHEEK POUCH ; IN-VITRO ; 1-DODECYLAZACYCLOHEPTAN-2-ONE AZONE ; PENETRATION ENHANCERS ; DRUG-DELIVERY ; PEPTIDE ; PROTEIN ; INVITRO ; PERMEABILITY
英文摘要

The effects of various transmucosal absorption enhancers on insulin permeation were studied in vitro and in vivo. The penetration of insulin through hamster and rabbit buccal membranes was investigated in vitro. The results showed that there was a statistically significant increase in the permeability of insulin compared with controls after concomitant administration with Brij 78, sodium deoxycholate, sodium lauryl sulfate and lecithin, but aprotinin, bacitracin, 1-menthol and poloxamer were less effective. The buccal delivery of insulin was investigated in vivo, in rats. Insulin absorption vas estimated from the cumulative response of the serum glucose concentration and in comparison to a SC dose/response curve. Buccal insulin efficacy in the absence of co-administration absorption enhancers was very low in relation to the SC administration of insulin. The values all increased significantly following concomitant administration via the buccal route with sodium deoxycholate, sodium lauryl sulfate, lecithin and Brij 78, Fr (relative pharmacological bioavailability) (P < 0.05). From the present studies, it is concluded that with the most effective absorption enhancers, buccal insulin vas one-fifth to one-fourth as effective as SC insulin. For the enhancement of these promoters, the results of in vitro experiments were in agreement with the in vivo results.

语种英语
WOS记录号WOS:000173532000002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53719
专题北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Hlth Sci Ctr, Dept Pharmaceut, Beijing 100083, Peoples R China
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GB/T 7714
Yang, TZ,Zhang, Q,Chen, DB,et al. Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies[J]. STP PHARMA SCIENCES,2001,11(6):415-419.
APA Yang, TZ,Zhang, Q,Chen, DB,&Nagai, T.(2001).Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies.STP PHARMA SCIENCES,11(6),415-419.
MLA Yang, TZ,et al."Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies".STP PHARMA SCIENCES 11.6(2001):415-419.
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