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学科主题: 药学
题名:
Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies
作者: Yang, TZ; Zhang, Q; Chen, DB; Nagai, T
关键词: buccal delivery ; absorption enhancers ; insulin ; permeability coefficient ; relative pharmacological bioavailability
刊名: STP PHARMA SCIENCES
发表日期: 2001-11-01
卷: 11, 期:6, 页:415-419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: KERATINIZED ORAL-MUCOSA ; HAMSTER-CHEEK POUCH ; IN-VITRO ; 1-DODECYLAZACYCLOHEPTAN-2-ONE AZONE ; PENETRATION ENHANCERS ; DRUG-DELIVERY ; PEPTIDE ; PROTEIN ; INVITRO ; PERMEABILITY
英文摘要:

The effects of various transmucosal absorption enhancers on insulin permeation were studied in vitro and in vivo. The penetration of insulin through hamster and rabbit buccal membranes was investigated in vitro. The results showed that there was a statistically significant increase in the permeability of insulin compared with controls after concomitant administration with Brij 78, sodium deoxycholate, sodium lauryl sulfate and lecithin, but aprotinin, bacitracin, 1-menthol and poloxamer were less effective. The buccal delivery of insulin was investigated in vivo, in rats. Insulin absorption vas estimated from the cumulative response of the serum glucose concentration and in comparison to a SC dose/response curve. Buccal insulin efficacy in the absence of co-administration absorption enhancers was very low in relation to the SC administration of insulin. The values all increased significantly following concomitant administration via the buccal route with sodium deoxycholate, sodium lauryl sulfate, lecithin and Brij 78, Fr (relative pharmacological bioavailability) (P < 0.05). From the present studies, it is concluded that with the most effective absorption enhancers, buccal insulin vas one-fifth to one-fourth as effective as SC insulin. For the enhancement of these promoters, the results of in vitro experiments were in agreement with the in vivo results.

语种: 英语
WOS记录号: WOS:000173532000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53719
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Hlth Sci Ctr, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Yang, TZ,Zhang, Q,Chen, DB,et al. Comparison of the effects of various transmucosal absorption enhancers on buccal insulin delivery: in vitro and in vivo studies[J]. STP PHARMA SCIENCES,2001,11(6):415-419.
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