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学科主题: 临床医学
题名:
Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer
作者: Ding, SG; Lin, SR; Dong, XY; Yang, XL; Qu, HY; Huang, SM; Liu, WJ; Zhou, LY; Liu, DH
关键词: gastric cancer ; vascular endothelial growth factor-A ; ELISA
刊名: IN VIVO
发表日期: 2005-07-01
卷: 19, 期:4, 页:793-795
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CARCINOMA ; CELLS ; VEGF
英文摘要:

Objective: The aim of this study was to evaluate the potential prognostic value of the circulating levels of vascular endothelial growth factor-A (VEGF-A) in patients with gastric cancer. Materials and Methods: An ELISA was used to quantify the serum and plasma levels of VEGF-A in 135 patients with gastric cancer and 48 controls with benign gastric diseases diagnosed by gastroendoscopy and histology of the biopsied specimens. Serum VEGF-A levels were assayed in controls (n = 10) and patients with gastric cancer (n = 10) prior to surgery. Further samples from 16 patients with gastric cancer, 3 weeks after tumour excision, were collected. Results: VEGF-A levels were significantly higher in both serum and plasma from patients with gastric cancer than those from the controls (serum: 342.1 pg/ml vs. 80.0 pg/ml, p < 0.01; plasma: 74.1 pg/ml vs. 23.7 pg/ml, p < 0.01). In both cancer patients prior to surgery and controls, serum VEGF-A levels appeared to be unchanged over a 7-day period. However, examination of paired samples from 16 cancer patients collected prior to surgery and 3 weeks post-surgery showed that tumor excision resulted in a significant decrease in VEGF-A levels (Paired t-test, t=5.4, p < 0.0001). Conclusion: Serum and plasma VEGF-A levels were significantly higher in patients with gastric cancer than in the controls. Serum VEGF-A levels correlated with tumour burden, as VEGF-A levels were significantly lowered following tumour excision in patients with gastric cancer.

语种: 英语
WOS记录号: WOS:000230097100023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53726
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100083, Peoples R China
2.Univ Manchester, Sch Med, Dept Pathol, Manchester M13 9PT, Lancs, England

Recommended Citation:
Ding, SG,Lin, SR,Dong, XY,et al. Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer[J]. IN VIVO,2005,19(4):793-795.
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