IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer
Ding, SG; Lin, SR; Dong, XY; Yang, XL; Qu, HY; Huang, SM; Liu, WJ; Zhou, LY; Liu, DH
关键词Gastric Cancer Vascular Endothelial Growth Factor-a Elisa
刊名IN VIVO
2005-07-01
19期:4页:793-795
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CARCINOMA ; CELLS ; VEGF
英文摘要

Objective: The aim of this study was to evaluate the potential prognostic value of the circulating levels of vascular endothelial growth factor-A (VEGF-A) in patients with gastric cancer. Materials and Methods: An ELISA was used to quantify the serum and plasma levels of VEGF-A in 135 patients with gastric cancer and 48 controls with benign gastric diseases diagnosed by gastroendoscopy and histology of the biopsied specimens. Serum VEGF-A levels were assayed in controls (n = 10) and patients with gastric cancer (n = 10) prior to surgery. Further samples from 16 patients with gastric cancer, 3 weeks after tumour excision, were collected. Results: VEGF-A levels were significantly higher in both serum and plasma from patients with gastric cancer than those from the controls (serum: 342.1 pg/ml vs. 80.0 pg/ml, p < 0.01; plasma: 74.1 pg/ml vs. 23.7 pg/ml, p < 0.01). In both cancer patients prior to surgery and controls, serum VEGF-A levels appeared to be unchanged over a 7-day period. However, examination of paired samples from 16 cancer patients collected prior to surgery and 3 weeks post-surgery showed that tumor excision resulted in a significant decrease in VEGF-A levels (Paired t-test, t=5.4, p < 0.0001). Conclusion: Serum and plasma VEGF-A levels were significantly higher in patients with gastric cancer than in the controls. Serum VEGF-A levels correlated with tumour burden, as VEGF-A levels were significantly lowered following tumour excision in patients with gastric cancer.

语种英语
WOS记录号WOS:000230097100023
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53726
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100083, Peoples R China
2.Univ Manchester, Sch Med, Dept Pathol, Manchester M13 9PT, Lancs, England
推荐引用方式
GB/T 7714
Ding, SG,Lin, SR,Dong, XY,et al. Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer[J]. IN VIVO,2005,19(4):793-795.
APA Ding, SG.,Lin, SR.,Dong, XY.,Yang, XL.,Qu, HY.,...&Liu, DH.(2005).Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer.IN VIVO,19(4),793-795.
MLA Ding, SG,et al."Potential prognostic value of circulating levels of vascular endothelial growth factor-A in patients with gastric cancer".IN VIVO 19.4(2005):793-795.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ding, SG]的文章
[Lin, SR]的文章
[Dong, XY]的文章
百度学术
百度学术中相似的文章
[Ding, SG]的文章
[Lin, SR]的文章
[Dong, XY]的文章
必应学术
必应学术中相似的文章
[Ding, SG]的文章
[Lin, SR]的文章
[Dong, XY]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。