IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells
Zhang, Yanling1,2; Zhang, Hong1; Hou, Ping1; Liang, Xiubin1; Li, Zhuo1; Wang, Haiyan1
关键词Angrem104 Glucocorticoid Receptor Nf-kappa b Mesangial Cells
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-05-16
DOI10.1016/j.bbrc.2008.02.148
369期:4页:1057-1060
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]TRANSACTIVATION DOMAIN ; ANGIOTENSIN-II ; COMPLEX ; INVOLVEMENT ; SUPPRESSION
英文摘要

AngRem104 [angiotensin II (Ang II)-related genes in human mesangial cells (MCs), clone104], a novel gene in human MCs induced by Ang II, was previously identified in human MCs and found to interact with several proteins. The current study used a yeast two-hybrid system and co-immunoprecipitation to investigate the interaction between AngRem104 and glucocorticoid receptor (GR) AF-1-specific elongation factor (GR-EF). GR expression was downregulated and the number of MCs positive for activated nuclear factor kappa B (NF-kappa B) was increased when AngRem104 was overexpressed. Transfection with antisense AngRem104 vector resulted in the upregulation of GR protein and reduced numbers of MCs with activated NF-kappa B. These results indicate that the novel gene AngRem-104 is involved in the in vivo regulation of GR expression and the activation of NF-kappa B through interaction with GR-EF in human MCs. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000254864700013
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53731
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Hebei Med Univ, Hosp 3, Dept Nephrol, Shijiazhuang 050051, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yanling,Zhang, Hong,Hou, Ping,et al. The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(4):1057-1060.
APA Zhang, Yanling,Zhang, Hong,Hou, Ping,Liang, Xiubin,Li, Zhuo,&Wang, Haiyan.(2008).The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(4),1057-1060.
MLA Zhang, Yanling,et al."The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 369.4(2008):1057-1060.
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