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学科主题: 临床医学
题名:
The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells
作者: Zhang, Yanling1,2; Zhang, Hong1; Hou, Ping1; Liang, Xiubin1; Li, Zhuo1; Wang, Haiyan1
关键词: AngRem104 ; glucocorticoid receptor ; NF-kappa B ; mesangial cells
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-05-16
DOI: 10.1016/j.bbrc.2008.02.148
卷: 369, 期:4, 页:1057-1060
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: TRANSACTIVATION DOMAIN ; ANGIOTENSIN-II ; COMPLEX ; INVOLVEMENT ; SUPPRESSION
英文摘要:

AngRem104 [angiotensin II (Ang II)-related genes in human mesangial cells (MCs), clone104], a novel gene in human MCs induced by Ang II, was previously identified in human MCs and found to interact with several proteins. The current study used a yeast two-hybrid system and co-immunoprecipitation to investigate the interaction between AngRem104 and glucocorticoid receptor (GR) AF-1-specific elongation factor (GR-EF). GR expression was downregulated and the number of MCs positive for activated nuclear factor kappa B (NF-kappa B) was increased when AngRem104 was overexpressed. Transfection with antisense AngRem104 vector resulted in the upregulation of GR protein and reduced numbers of MCs with activated NF-kappa B. These results indicate that the novel gene AngRem-104 is involved in the in vivo regulation of GR expression and the activation of NF-kappa B through interaction with GR-EF in human MCs. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000254864700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53731
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Hebei Med Univ, Hosp 3, Dept Nephrol, Shijiazhuang 050051, Peoples R China

Recommended Citation:
Zhang, Yanling,Zhang, Hong,Hou, Ping,et al. The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappa B in human mesangial cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(4):1057-1060.
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