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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Combination of microtubule associated protein-tau and beta-tubulin III predicts chemosensitivity of paclitaxel in patients with advanced gastric cancer
作者: Yu, Jingwei1; Gao, Jing1; Lu, Zhihao1; Gong, Jifang1; Li, Yanyan1; Dong, Bin2; Li, Zhongwu2; Zhang, Xiaotian1; Shen, Lin1
关键词: MAP-tau ; TUBB3 ; Paclitaxel ; Gastric cancer
刊名: EUROPEAN JOURNAL OF CANCER
发表日期: 2014-09-01
DOI: 10.1016/j.ejca.2014.06.017
卷: 50, 期:13, 页:2328-2335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CANCER ; BREAST-CANCER ; PREOPERATIVE CHEMOTHERAPY ; BINDING AGENTS ; EXPRESSION ; MARKER ; RESISTANCE ; TAXANES ; SENSITIVITY ; DOXORUBICIN
英文摘要:

Aim: To investigate the role of microtubule associated proteiti-tau (MAP-tau) and beta-tubulin III (TUBB3) in predicting the chemosensitivity of paclitaxel in patients with advanced gastric cancer (GC).

Methods: MAP-tau and TUBB3 expressions were detected using immunohistochemistry in 244 advanced GC patients prior to chemotherapy. The associations of MAP-tau and TUBB3 expressions with paclitaxel sensitivity were assessed using in vitro and in vivo xenograft analysis.

Results: A total of 149 patients receiving paclitaxel plus capecitabine (cohort 1) and 95 patients receiving cisplatin plus capecitabine (cohort 2) were included in this study. In cohort 1, the clinical benefit rate (CBR), median progression-free survival (PFS) and overall survival (OS) were found to be significantly higher in patients with low levels of MAP-tau and TUBB3 expressions and were significantly higher than those in patients with high levels of MAP-tau and TUBB3 expressions (CBR: 72.2% versus 35.9%; PFS: 271 versus 102 days; OS: 394 versus 173 days; all P < 0.05). This was not observed in cohort 2. In in vitro studies, the sensitivity of paclitaxel in human gastric cancer cells was inversely correlated with the expression levels of MAP-tau and TUBB3, as in in vivo animal xenografts.

Conclusions: The combination of MAP-tau and TUBB3 was found to predict chemosensitivity to paclitaxel in gastric cancer in vitro and in vivo. This merits further study and may help, guide individual therapy. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: Z11110706730000 ; 81172110 ; 2012AA 02A 504
项目资助者: Beijing Municipal Science &amp ; Technology Commission Program ; National Natural Science Foundation of China ; National High Technology Research and Development Program
WOS记录号: WOS:000340849800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53733
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ Canc Hosp & Inst, Minist Educ, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
2.Peking Univ Canc Hosp & Inst, Minist Educ, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

Recommended Citation:
Yu, Jingwei,Gao, Jing,Lu, Zhihao,et al. Combination of microtubule associated protein-tau and beta-tubulin III predicts chemosensitivity of paclitaxel in patients with advanced gastric cancer[J]. EUROPEAN JOURNAL OF CANCER,2014,50(13):2328-2335.
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