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学科主题: 临床医学
题名:
Classification criteria of early rheumatoid arthritis and validation of its performance in a multi-centre cohort
作者: Zhao, J.1,2; Su, Y.1; Li, R.1; Ye, H.1; Zou, Q.3; Fang, Y.3; Liu, H.4; Li, X.4; Guo, J.5; Bi, L.5; Gu, F.6; Sun, L.6; Mei, Y.7; Zhang, Z.7; Chen, L.8; Zhu, P.8; Li, G.9; Zhang, Z.9; Leng, X.10; Zhao, Y.10; Jiang, L.11; Zou, H.11; Zhao, Y.12; Liu, Y.12; Li, L.13; Wang, H.13; Liu, X.2; Li, Z.1
关键词: arthritis ; rheumatoid ; early ; classification criteria
刊名: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
发表日期: 2014-09-01
卷: 32, 期:5, 页:667-673
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: 2010 AMERICAN-COLLEGE ; 1987 ACR CRITERIA ; RHEUMATOLOGY/EUROPEAN LEAGUE ; ACR/EULAR CRITERIA ; REVISED CRITERIA
英文摘要:

Objective

To develop classification criteria for early rheumatoid arthritis (ERA) based on a large cohort of early inflammatory arthritis patients and to evaluate the performance of these criteria.

Methods

The study population comprised a cohort of early inflammatory arthritis patients with symptom duration less than one year. Classification criteria of ERA were developed by incorporating the most sensitive or specific variables. Performance of the ERA criteria, 1987 ACR and 2010 ACR/EULAR criteria were evaluated.

Results

A total of 803 patients were enrolled in this study. By the end of the one year follow-up, 514 patients were diagnosed with RA, 251 with other rheumatic diseases, and 38 patients with undifferentiated arthritis. The ERA criteria are as follows: 1) morning stiffness >= 30 minutes; 2) arthritis of 3 or more joint areas; 3) arthritis of hand joints; 4) positive RF; 5) positive anti-CCP antibody. Rheumatoid arthritis is defined by the presence of 3 or more of the criteria. The sensitivity (84.4%) of the ERA classification criteria was much higher than the 1987 ACR criteria (58.0%). In a validation cohort of early inflammatory arthritis patients, the area under the ROC curves (AUC) showed a better performance for the ERA criteria (0.906, 95%CI 0.866 to 0.945) than the 1987 ACR criteria (0.786, 95%CI 0.725 to 0.848) and the 2010 ACR/EULAR criteria (0.745, 95%CI 0.677 to 0.814).

Conclusion

A set of ERA classification criteria has been developed with good performance for early RA. It is applicable in clinical. practice and research.

语种: 英语
WOS记录号: WOS:000343633200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53738
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100191, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Dept Rheumatol & Immunol, Chongqing, Peoples R China
4.Shandong Univ, Dept Rheumatol & Immunol, Qilu Hosp, Jinan, Shandong, Peoples R China
5.Jilin Univ, Dept Rheumatol & Immunol, China Japan Union Hosp, Changchun, Peoples R China
6.Nanjing Univ, Dept Rheumatol & Immunol, Affiliated Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China
7.Harbin Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Harbin, Peoples R China
8.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Immunol, Xian, Peoples R China
9.Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
10.Beijing Union Med Coll Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
11.Fudan Univ, Huashan Hosp, Dept Rheumatol, Shanghai, Peoples R China
12.Sichuan Univ, West China Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China
13.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, J.,Su, Y.,Li, R.,et al. Classification criteria of early rheumatoid arthritis and validation of its performance in a multi-centre cohort[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2014,32(5):667-673.
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