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学科主题: 口腔医学
题名:
Risk factors and treatment of contralateral neck recurrence for unilateral oral squamous cell carcinoma: A retrospective study of 1482 cases
作者: Feng, Zhien; Niu, Li Xuan; Yuan, Yuan; Peng, Xin; Guo, Chuan Bin
关键词: Oral squamous cell carcinoma ; Neck dissection ; Lymph nodal metastasis ; Contralateral neck recurrence ; Prognosis ; Risk factor
刊名: ORAL ONCOLOGY
发表日期: 2014-11-01
DOI: 10.1016/j.oraloncology.2014.08.003
卷: 50, 期:11, 页:1081-1088
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]: LYMPH-NODE METASTASES ; PROGNOSTIC-FACTORS ; CAVITY ; DISSECTION ; TONGUE ; HEAD ; CHEMOTHERAPY ; MANAGEMENT ; SURVIVAL ; CANCER
英文摘要:

Background: The aim of this study was to describe risk factors of contralateral neck recurrence (CLNR) and to identify its high-risk population after treatment for unilateral oral squamous cell carcinoma.

Methods: Between June 1991 and June 2012, a total of 1482 eligible patients who were treated with radical surgery with or without adjuvant therapy were retrospectively reviewed.

Results: The outcome assessment parameters were the rate of 5-year CLNR and the rate of disease-specific survival (DSS). In the entire study cohort, the 5-year CLNR rate was 4.1%. In a multivariate analysis, only extracapsular spread (ECS) status (hazard ratio [HR]: 12.978, 95% confidence interval [CI]: 1.328-126.829, P = 0.028) was an independent risk factor for 5-year CLNR. In addition, 5-year CLNR (HR: 36.410, 95% CI: 7.093-186.914, P < 0.001), T stage (HR: 3.475, 95% CI: 1.151-10.488, P = 0.027) and growth pattern (HR: 4.831, 95% CI: 1.776-13.140, P = 0.002) were independent risk factors for 5-year DSS. Patients with at least two risk factors were identified as a high-risk population for CLNR; these patients also had a poor prognosis. Elective contralateral neck dissection (ND) plus concurrent chemoradiotherapy (CCRT) can improve the 5-year DSS in these high-risk patients, but it does not decrease the 5-year CLNR rate.

Conclusion: For low-and moderate-risk patients, contralateral neck observation should be considered sufficient if strict compliance with a cancer surveillance protocol is followed. However, whether high-risk patients benefit from contralateral ND plus adjuvant CCRT can only be answered in a prospective trial. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81302350 ; 7144258 ; 2014T70018 ; 2009AA045201
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; China Postdoctoral Science Foundation ; National High Technology Research and Development Program of China
WOS记录号: WOS:000344066500013
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53739
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Feng, Zhien,Niu, Li Xuan,Yuan, Yuan,et al. Risk factors and treatment of contralateral neck recurrence for unilateral oral squamous cell carcinoma: A retrospective study of 1482 cases[J]. ORAL ONCOLOGY,2014,50(11):1081-1088.
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