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学科主题: 药学
题名:
Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells
作者: Tong, Jing1; Yin, Shutao1; Dong, Yinhui1; Guo, Xiao1; Fan, Lihong2; Ye, Min3; Hu, Hongbo1
关键词: pseudolaric acid B ; prostate cancer ; apoptosis ; autophagic cell death ; sensitization
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2013-06-01
DOI: 10.1002/ptr.4808
卷: 27, 期:6, 页:885-891
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: N-TERMINAL KINASE ; SENSITIZATION ; ARREST ; AGENT ; MCF-7 ; JNK ; CHEMOPREVENTION ; DITERPENOIDS ; DEGRADATION ; ACTIVATION
英文摘要:

Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer. The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity. Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer. Copyright (c) 2012 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 31071533 ; 30972172 ; 2012BAD33B09
项目资助者: National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China
WOS记录号: WOS:000320114500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53740
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.China Agr Univ, Coll Food Sci & Nutr Engn, Div Nutr & Hlth, Beijing 100083, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Tong, Jing,Yin, Shutao,Dong, Yinhui,et al. Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells[J]. PHYTOTHERAPY RESEARCH,2013,27(6):885-891.
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