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Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells
Tong, Jing1; Yin, Shutao1; Dong, Yinhui1; Guo, Xiao1; Fan, Lihong2; Ye, Min3; Hu, Hongbo1
关键词Pseudolaric Acid b Prostate Cancer Apoptosis Autophagic Cell Death Sensitization
刊名PHYTOTHERAPY RESEARCH
2013-06-01
DOI10.1002/ptr.4808
27期:6页:885-891
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]N-TERMINAL KINASE ; SENSITIZATION ; ARREST ; AGENT ; MCF-7 ; JNK ; CHEMOPREVENTION ; DITERPENOIDS ; DEGRADATION ; ACTIVATION
英文摘要

Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer. The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity. Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer. Copyright (c) 2012 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000320114500014
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53740
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.China Agr Univ, Coll Food Sci & Nutr Engn, Div Nutr & Hlth, Beijing 100083, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Tong, Jing,Yin, Shutao,Dong, Yinhui,et al. Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells[J]. PHYTOTHERAPY RESEARCH,2013,27(6):885-891.
APA Tong, Jing.,Yin, Shutao.,Dong, Yinhui.,Guo, Xiao.,Fan, Lihong.,...&Hu, Hongbo.(2013).Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells.PHYTOTHERAPY RESEARCH,27(6),885-891.
MLA Tong, Jing,et al."Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells".PHYTOTHERAPY RESEARCH 27.6(2013):885-891.
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