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学科主题: 临床医学
题名:
Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients
作者: Zhuo HongQing; Jiang KeWei; Dong LingYi; Zhu Yi; Lu Liang; Lu You; Zhang YanBin; Zhang Hui; Ye YingJiang; Wang Shan
关键词: colorectal neoplasms ; N-cadherin ; immunohistochemistry ; prognosis
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2013-10-01
DOI: 10.1007/s11434-013-5813-3
卷: 58, 期:28-29, 页:3529-3534
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ; CELL-CELL-ADHESION ; PROSTATE-CANCER ; BREAST-CANCER ; HEPATOCELLULAR-CARCINOMA ; TUMOR-METASTASIS ; EXPRESSION ; MIGRATION ; INVASION ; IDENTIFICATION
英文摘要:

N-cadherin is related to the progression and metastases of several solid carcinomas. However, it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency. In this study, we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120 patients with colorectal cancer. We revealed that N-cadherin was expressed in 78.3% (94/120) of colorectal tumor tissues and in only 9.2% (11/120) of paired distant normal mucosa tissues with a significant difference (P=0.000). The low, moderate, and high expression of N-cadherin protein was 42.5%, 30.8%, and 26.7%, respectively. N-cadherin overexpression was associated with advanced TNM stage, lymph nodes metastasis and distant metastasis (P < 0.05). Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression, and patients with low expression had a better survival rate than those with moderate and high expression (P < 0.05). In conclusion, high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer, and may prove to be a possible prognostic factor.

语种: 英语
所属项目编号: 20090001120082 ; 81072018 ; 81172272
项目资助者: Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China
WOS记录号: WOS:000325689600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53742
Appears in Collections:北京大学第二临床医学院_外科肿瘤研究室_期刊论文

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作者单位: Peking Univ, Dept Gastrointestinall Surg, Lab Surg Oncol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zhuo HongQing,Jiang KeWei,Dong LingYi,et al. Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients[J]. CHINESE SCIENCE BULLETIN,2013,58(28-29):3529-3534.
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