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学科主题: 基础医学
题名:
Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo
作者: Chang, Ying1,2; Li, Yanjun1,2; Hu, Jia1,2; Guo, Jinhai3; Xu, Dong1,2; Xie, Hong1; Lv, Xiaodong1; Shi, Taiping3; Chen, Yingyu1,2
关键词: TMEM166 ; Adenovirus vector ; Autophagy ; Apoptosis ; Anti-tumor activity
刊名: CANCER LETTERS
发表日期: 2013
DOI: 10.1016/j.canlet.2012.08.032
卷: 328, 期:1, 页:126-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TUMOR-SUPPRESSOR ; PROTEIN ; BECLIN-1 ; DEATH ; GENE ; MACROAUTOPHAGY ; TUMORIGENESIS ; THERAPY ; COMPLEX ; KINASE
英文摘要:

TMEM166 is a novel programmed cell death-related molecule. In this report, we constructed a recombinant adenovirus 5-TMEM166 vector (Ad5-TMEM166) and evaluated its expression and anti-tumor activities in vitro and in vivo. Cell viability analysis revealed that the adenovirus-mediated increase of TMEM166 inhibited tumor cell growth in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy (via inhibition of mTOR and activation of p70S6K) and apoptosis (via caspase-3 activation), both of which contributed to cell death and suppression of tumorigenicity. Our data indicated that Ad5-TMEM166 may be a novel gene therapy candidate for cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB910103 ; 30771057
项目资助者: National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China
WOS记录号: WOS:000311661700015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53744
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
3.Chinese Natl Human Genome Ctr, Beijing, Peoples R China

Recommended Citation:
Chang, Ying,Li, Yanjun,Hu, Jia,et al. Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo[J]. CANCER LETTERS,2013,328(1):126-134.
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