IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo
Chang, Ying1,2; Li, Yanjun1,2; Hu, Jia1,2; Guo, Jinhai3; Xu, Dong1,2; Xie, Hong1; Lv, Xiaodong1; Shi, Taiping3; Chen, Yingyu1,2
关键词TMEM166 Adenovirus vector Autophagy Apoptosis Anti-tumor activity
刊名CANCER LETTERS
2013
DOI10.1016/j.canlet.2012.08.032
328期:1页:126-134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China ; National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR ; PROTEIN ; BECLIN-1 ; DEATH ; GENE ; MACROAUTOPHAGY ; TUMORIGENESIS ; THERAPY ; COMPLEX ; KINASE
英文摘要

TMEM166 is a novel programmed cell death-related molecule. In this report, we constructed a recombinant adenovirus 5-TMEM166 vector (Ad5-TMEM166) and evaluated its expression and anti-tumor activities in vitro and in vivo. Cell viability analysis revealed that the adenovirus-mediated increase of TMEM166 inhibited tumor cell growth in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy (via inhibition of mTOR and activation of p70S6K) and apoptosis (via caspase-3 activation), both of which contributed to cell death and suppression of tumorigenicity. Our data indicated that Ad5-TMEM166 may be a novel gene therapy candidate for cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2011CB910103 ; 30771057
资助者National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China ; National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China
WOS记录号WOS:000311661700015
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53744
Collection北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
3.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chang, Ying,Li, Yanjun,Hu, Jia,et al. Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo[J]. CANCER LETTERS,2013,328(1):126-134.
APA Chang, Ying.,Li, Yanjun.,Hu, Jia.,Guo, Jinhai.,Xu, Dong.,...&Chen, Yingyu.(2013).Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo.CANCER LETTERS,328(1),126-134.
MLA Chang, Ying,et al."Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo".CANCER LETTERS 328.1(2013):126-134.
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