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学科主题: 临床医学
题名:
Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives
作者: Liu, H.2; Zhang, S.1; Jiang, S.2; Mao, G.3; Hong, X.2; Yu, Y.2; Zhang, Y.4; Tang, G.3; Xing, H.3; Xu, X.1,2,3
关键词: blood pressure response ; irbesartan ; polymorphism ; renin-angiotensin-aldosterone system
刊名: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
发表日期: 2008-05-01
DOI: 10.1358/mf.2008.30.4.1196077
卷: 30, 期:4, 页:307-312
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BLOOD-PRESSURE ; SYNTHASE GENE ; C-344T POLYMORPHISM ; PLASMA-ALDOSTERONE ; CYP11B2 ; ASSOCIATION ; POPULATION ; MANAGEMENT ; VARIANTS ; ACE
英文摘要:

The aim of this study was to determine whether specific single nucleotide polymorphisms (SNPs) and their reconstructed haplotypes in renin-angiotensin-aldosterone system (RAAS) genes were associated with antihypertensive reduction to irbesartan treatment. Thousand one forty-two hypertensives were recruited and received 150 mg irbesartan daily for 4 weeks. Blood pressures (BPs) and blood samples, at postdose on the 28th day, were measured. Predose BPs and plasma irbesartan concentrations were also measured. Involved SNPs in RAAS pathway genes were genotyped. Genotype (-344 TC) in the CYP11B2 had a significantly greater systolic blood pressure (SBP) reduction versus the TT genotype (p = 0.001). Subjects with the 174MM genotype of the angiotensinogen (AGT) gene had a significantly greater average SLIP reduction (p = 0.025). The C-344T and T 1016C polymorphisms in the CYP11B2 gene were both significantly associated with diastolic blood pressure (DBP) reduction (p = 0.026 or p = 0.003). overall. the three loci-constructed haplotypes of the CYP11B2 gene were associated with DBP reduction (p = 0.008). Haplo- GLM analyses demonstrated that subjects with haplotype CTA had a significantly greater SBP and DBP reductions (p < 0.001 or p = 0.020), whereas subjects with haplotype TAA had a significantly lower SBP and DBP reductions (p < 0.001). Our findings suggested that SNPs and their reconstructed haplotypes in RAAS genes might be involved in the regulation of BP-lowering response to irbesartan in Chinese hypertensives. copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.

语种: 英语
WOS记录号: WOS:000259022400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53752
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Anhui, Peoples R China
2.Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Ctr Populat Genet, Chicago, IL 60612 USA
3.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
4.Peking Univ, Hosp 1, Dept Cardiovasc Dis, Beijing, Peoples R China

Recommended Citation:
Liu, H.,Zhang, S.,Jiang, S.,et al. Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives[J]. METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY,2008,30(4):307-312.
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