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学科主题: 基础医学
题名:
Endothelial damage and stem cell repair in atherosclerosis
作者: Bai, Xue1,2; Wang, Xian2; Xu, Qingbo1
关键词: Endothelial cells ; Shear stress ; Stem cells ; Repair ; Atherosclerosis
刊名: VASCULAR PHARMACOLOGY
发表日期: 2010-05-01
DOI: 10.1016/j.vph.2010.02.001
卷: 52, 期:5-6, 页:224-229
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; SMOOTH-MUSCLE-CELLS ; CIRCULATING PROGENITOR CELLS ; TRANSCRIPTION FACTOR XBP-1 ; FLUID SHEAR-STRESS ; BONE-MARROW CELLS ; IN-VIVO ; ENDOPLASMIC-RETICULUM ; ARTERIAL INJURY ; TRANSPLANT ARTERIOSCLEROSIS
英文摘要:

Atherosclerosis is a slowly progressing and multifactorial disease, in which endothelial dysfunction and damage play an initial role. Many risk factors for atherosclerosis can lead to endothelial damage of the vessel, especially in the areas where blood flow is disturbed. In the presence of hyperlipidemia, disturbed blood flow results in increased endothelial turnover in the arterial wall. It was demonstrated that disturbed blood flow activates endoplasmic reticulum stress initiating a signal pathway leading to endothelial apoptosis. Following endothelial death, the neighboring mature endothelial cells actively proliferate and migrate to heal the wound. However, stem cell repairing may be needed if endothelial damage is severe. As rapid development of stem cell research, it is expected that stem/progenitor cells may serve as a new source for vascular repair. In this review, we aim at examining key elements of endothelial turnover in atherosclerosis, i.e. damage and repair. We will also discuss the mechanisms of the process repaired by mature endothelial as well as stem cells, and highlight recent reciprocal stem cell application, which may provide a new hope to the treatment of severe atherosclerotic complications. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: British Heart Foundation ; Oak Foundation
WOS记录号: WOS:000277447100009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53757
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: 1.Kings Coll London, Div Cardiovasc, BHF Ctr, London SE5 9NU, England
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China

Recommended Citation:
Bai, Xue,Wang, Xian,Xu, Qingbo. Endothelial damage and stem cell repair in atherosclerosis[J]. VASCULAR PHARMACOLOGY,2010,52(5-6):224-229.
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