IR@PKUHSC  > 北京大学基础医学院  > 生理学与病理生理学系
学科主题基础医学
Endothelial damage and stem cell repair in atherosclerosis
Bai, Xue1,2; Wang, Xian2; Xu, Qingbo1
关键词Endothelial cells Shear stress Stem cells Repair Atherosclerosis
刊名VASCULAR PHARMACOLOGY
2010-05-01
DOI10.1016/j.vph.2010.02.001
52期:5-6页:224-229
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者British Heart Foundation ; Oak Foundation ; British Heart Foundation ; Oak Foundation
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]UNFOLDED PROTEIN RESPONSE ; SMOOTH-MUSCLE-CELLS ; CIRCULATING PROGENITOR CELLS ; TRANSCRIPTION FACTOR XBP-1 ; FLUID SHEAR-STRESS ; BONE-MARROW CELLS ; IN-VIVO ; ENDOPLASMIC-RETICULUM ; ARTERIAL INJURY ; TRANSPLANT ARTERIOSCLEROSIS
英文摘要

Atherosclerosis is a slowly progressing and multifactorial disease, in which endothelial dysfunction and damage play an initial role. Many risk factors for atherosclerosis can lead to endothelial damage of the vessel, especially in the areas where blood flow is disturbed. In the presence of hyperlipidemia, disturbed blood flow results in increased endothelial turnover in the arterial wall. It was demonstrated that disturbed blood flow activates endoplasmic reticulum stress initiating a signal pathway leading to endothelial apoptosis. Following endothelial death, the neighboring mature endothelial cells actively proliferate and migrate to heal the wound. However, stem cell repairing may be needed if endothelial damage is severe. As rapid development of stem cell research, it is expected that stem/progenitor cells may serve as a new source for vascular repair. In this review, we aim at examining key elements of endothelial turnover in atherosclerosis, i.e. damage and repair. We will also discuss the mechanisms of the process repaired by mature endothelial as well as stem cells, and highlight recent reciprocal stem cell application, which may provide a new hope to the treatment of severe atherosclerotic complications. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

语种英语
资助者British Heart Foundation ; Oak Foundation ; British Heart Foundation ; Oak Foundation
WOS记录号WOS:000277447100009
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53757
Collection北京大学基础医学院_生理学与病理生理学系
作者单位1.Kings Coll London, Div Cardiovasc, BHF Ctr, London SE5 9NU, England
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Bai, Xue,Wang, Xian,Xu, Qingbo. Endothelial damage and stem cell repair in atherosclerosis[J]. VASCULAR PHARMACOLOGY,2010,52(5-6):224-229.
APA Bai, Xue,Wang, Xian,&Xu, Qingbo.(2010).Endothelial damage and stem cell repair in atherosclerosis.VASCULAR PHARMACOLOGY,52(5-6),224-229.
MLA Bai, Xue,et al."Endothelial damage and stem cell repair in atherosclerosis".VASCULAR PHARMACOLOGY 52.5-6(2010):224-229.
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