IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies
Huang, X. -J.; Liu, D. -H.; Liu, K. -Y.; Xu, L. -P.; Chen, H.; Han, W.; Chen, Y. -H.; Wang, J. -Z.; Gao, Z. -Y.; Zhang, Y. -C.; Jiang, Q.; Shi, H. -X.; Lu, D. -P.
关键词Hematopoietic Stem Cell Transplantation Allogeneic Hla Mismatched Haploidentical
刊名BONE MARROW TRANSPLANTATION
2006-08-01
DOI10.1038/sj.bmt.1705445
38期:4页:291-297
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; COLONY-STIMULATING FACTOR ; MARROW-TRANSPLANTATION ; BONE-MARROW ; ACUTE-LEUKEMIA ; SURVIVAL ; PROPHYLAXIS ; ENGRAFTMENT ; DONORS
英文摘要

Many patients who require allogeneic hematopoietic stem cell transplantation (allo-HSCT) lack a human leukocyte antigen (HLA)-matched donor. Here, we report a protocol for haploidentical allo-HSCT that combines granulocyte-colony stimulating factor primed bone marrow (G-BM) and peripheral blood stem cells (PBSC) without in vitro T-cell depletion (TCD). In this study, 171 patients, including 86 in high-risk group, underwent transplantation from haploidentical family donors. All patients achieved sustained, full donor chimerism. One hundred and eleven patients were alive in remission at a median of 682 (253-1502) days. The cumulative incidence of grade III-IV acute graft-versus-host disease (GVHD) was 23% and that of extensive chronic GVHD, 47%; these were not influenced by HLA disparity. Patients younger than 15 years had less grade III-IV acute GVHD than older patients (P = 0.044). The 2-year probability of relapse was 12% for standard-risk disease and 39% for high-risk disease. The 2-year probability of leukemia-free survival (LFS) was 68% for standard-risk patients and 42% for high-risk patients (P = 0.0009). Grade III-IV acute GVHD was associated with better LFS (P = 0.0017). The results require confirmation and show that G-BM combined with PBSC from haploidentical family donors, without in vitro TCD, maybe used as a good source of stem cells for allo-HSCT.

语种英语
WOS记录号WOS:000239598900005
引用统计
被引频次:207[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53759
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Xicheng Distric, Peoples R China
推荐引用方式
GB/T 7714
Huang, X. -J.,Liu, D. -H.,Liu, K. -Y.,et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies[J]. BONE MARROW TRANSPLANTATION,2006,38(4):291-297.
APA Huang, X. -J..,Liu, D. -H..,Liu, K. -Y..,Xu, L. -P..,Chen, H..,...&Lu, D. -P..(2006).Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies.BONE MARROW TRANSPLANTATION,38(4),291-297.
MLA Huang, X. -J.,et al."Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies".BONE MARROW TRANSPLANTATION 38.4(2006):291-297.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, X. -J.]的文章
[Liu, D. -H.]的文章
[Liu, K. -Y.]的文章
百度学术
百度学术中相似的文章
[Huang, X. -J.]的文章
[Liu, D. -H.]的文章
[Liu, K. -Y.]的文章
必应学术
必应学术中相似的文章
[Huang, X. -J.]的文章
[Liu, D. -H.]的文章
[Liu, K. -Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。