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学科主题: 临床医学
题名:
The Direct Biologic Effects of Radioactive I-125 Seeds on Pancreatic Cancer Cells PANC-1, at Continuous Low-Dose Rates
作者: Wang, Jidong1; Wang, Junjie1; Iiao, Anyan1; Zhuang, Hongqing1; Zhao, Yong2
关键词: I-125 seed ; interstitial brachytherapy ; relative biologic effectiveness ; apoptosis ; cell cycle
刊名: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
发表日期: 2009-08-01
DOI: 10.1089/cbr.2008.0563
卷: 24, 期:4, 页:409-416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CO-60 GAMMA-RAYS ; IN-VITRO ; BEAM IRRADIATION ; I125 IMPLANT ; CYCLE ARREST ; RADIATION ; CARCINOMA ; BRACHYTHERAPY ; APOPTOSIS ; PD-103
英文摘要:

The relative biologic effectiveness of model 6711 I-125 seeds (Ningbo Junan Pharmaceutical Technology Company, Ningbo, China) and their effects on growth, cell cycle, and apoptosis in human pancreatic cancer cell line PANC-1 were examined in the present study. PANC-1 cells were exposed to the absorbed doses of 1, 2, 4, 6, 8, and 10 Gy either with I-125 seeds (initial dose rate, 2.59 cGy/h) or with Co-60 gamma-ray irradiation (dose rate, 221 cGy/min), respectively. Significantly greater numbers of apoptotic PANC-1 cells were detected following the continuous low-dose-rate (CLDR) irradiation of I-125 seeds, compared with cells irradiated with identical doses of Co-60 gamma-ray. The D-0 for Co-60 gamma-ray and I-125 seed irradiation were 2.30 and 1.66, respectively. The survival fraction after I-125 seed irradiation was significantly lower than that of Co-60 gamma-ray, with a relative biologic effectiveness of 1.39. PANC-1 cells were dose dependently arrested in the S-phase by Co-60 gamma-rays and in the G2/M phase by I-125 seeds, 24 hour after irradiation. CLDR irradiation by I-125 seeds was more effective in inducing cell apoptosis in PANC-1 cells than acute high-dose-rate Co-60 gamma Irradiation. interestingly, CLDR irradiation by I-125 seeds can cause PANC-1 cell-cycle arrest at the G2/M phase and induce apoptosis, which may be an important mechanism underlying I-125 seed-induced PANC-1 cell inhibition.

语种: 英语
所属项目编号: 39900167
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000269156300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53762
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Ctr Canc, Hosp 3, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China

Recommended Citation:
Wang, Jidong,Wang, Junjie,Iiao, Anyan,et al. The Direct Biologic Effects of Radioactive I-125 Seeds on Pancreatic Cancer Cells PANC-1, at Continuous Low-Dose Rates[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2009,24(4):409-416.
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