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学科主题: 基础医学
题名:
Targeted Bioimaging and Photodynamic Therapy of Cancer Cells with an Activatable Red Fluorescent Bioprobe
作者: Hu, Fang1; Huang, Yanyan1; Zhang, Guanxin1; Zhao, Rui1; Yang, Hua2; Zhang, Deqing1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2014-08-05
DOI: 10.1021/ac502103t
卷: 86, 期:15, 页:7987-7995
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: AGGREGATION-INDUCED EMISSION ; TURN-ON DETECTION ; IN-VIVO ; HEPATOCELLULAR-CARCINOMA ; RATIONAL DESIGN ; LIGHT ; PHOTOSENSITIZERS ; TETRAPHENYLETHYLENE ; PEPTIDE ; NANOPLATFORM
英文摘要:

A new red-emissive bioprobe TPE-red-2AP2H was developed by taking advantage of the unique emission feature of tetraphenylethylene and a cancer cell-specific peptide. By responding to the target protein and the acidic micro-environment of tumor cells, activated fluorescence bioimaging was achieved with high signal-to-noise ratio and without involving mutiple washing steps. Apart from targeting the membrane-anchored LAPTM4B proteins, TPE-red-2AP2H was successfully utilized to trace the intracellular movement of LAPTM4B protein. The generation of 102 under visible light irradiation makes this bioprobe also promising for targeted-photodynamic therapy. By discriminating the expression level of the target protein, TPE-red-2AP2H can respond to the progression status of tumors with different photodynamic therapy effect.

语种: 英语
所属项目编号: 21105105 ; 21321003 ; 21135006 ; 21190032
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
WOS记录号: WOS:000340081100115
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53763
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Chinese Acad Sci, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China

Recommended Citation:
Hu, Fang,Huang, Yanyan,Zhang, Guanxin,et al. Targeted Bioimaging and Photodynamic Therapy of Cancer Cells with an Activatable Red Fluorescent Bioprobe[J]. ANALYTICAL CHEMISTRY,2014,86(15):7987-7995.
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