IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT
Zhou, J; Scherlag, BJ; Yamanashi, W; Wu, R; Huang, Y; Lazzara, R; Jackman, WM; Po, SS
关键词Right Ventricular Outflow Tract Ventricular Tachycardia Sympathetic Nerve Autonomic Nervous System Ablation Ventromedial Cardiac Nerve Pulmonary Artery
刊名JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
2006-07-01
DOI10.1111/j.1540-8167.2006.00509.x
17期:7页:771-775
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]RADIOFREQUENCY CATHETER ABLATION ; BUNDLE-BRANCH BLOCK ; PULMONARY-ARTERY ; ORIGIN ; SYSTEM
英文摘要

Objective: To simulate right ventricular outflow tract tachycardia (RVOT-VT) in experimental animals.

Background: The mechanism(s) whereby a discrete area of myocardium in the RVOT becomes arrhythmogenic remains unknown.

Methods: In 13 dogs, a circular catheter was placed in the proximal pulmonary artery (PA) to contact the endovascular circumference of the PA. A 50-msec train of high-frequency stimulation (HFS, 200 Hz), coupled to atrial pacing, was applied at each bipolar pair of the circular catheter. The coupling interval was adjusted so that the 50-msec train occurred during the ventricular refractory period, that is, the QRS complex, in order to prevent stimulation of the myocardial sleeve within the proximal PA.

Results: In all dogs, HFS induced ventricular premature depolarizations and VTs with a left bundle branch block (LBBB) morphology and inferior axis (average 6.8 +/- 1.6 V). Earliest activation was consistently recorded from the proximal PA. Esmolol, a short-acting beta-blocker (1 mg/kg), was administered intravenously in 11 dogs. The inducible ventricular ectopy was abolished in 10 dogs (> 12 V, P < 0.05) and the response to HFS was blunted in one dog (10-11 V). After 30 minutes, the response to HFS returned to pre-esmolol levels.

Conclusions: Stimulation of the sympathetic input to the proximal PA induces ventricular ectopy and VTs exhibiting a left bundle branch block morphology and inferior axis, closely simulating clinical RVOT-VT. Beta-blockade either abolishes or blunts this response, corroborating the sympathetic etiology in this model and in some clinical cases of RVOT tachycardias.

语种英语
WOS记录号WOS:000238395900016
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53765
Collection北京大学第一临床医学院_心血管内科
作者单位1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
3.Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China
Recommended Citation
GB/T 7714
Zhou, J,Scherlag, BJ,Yamanashi, W,et al. Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2006,17(7):771-775.
APA Zhou, J.,Scherlag, BJ.,Yamanashi, W.,Wu, R.,Huang, Y.,...&Po, SS.(2006).Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT.JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,17(7),771-775.
MLA Zhou, J,et al."Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT".JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 17.7(2006):771-775.
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