北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT
作者: Zhou, J; Scherlag, BJ; Yamanashi, W; Wu, R; Huang, Y; Lazzara, R; Jackman, WM; Po, SS
关键词: right ventricular outflow tract ; ventricular tachycardia ; sympathetic nerve ; autonomic nervous system ; ablation ; ventromedial cardiac nerve ; pulmonary artery
刊名: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
发表日期: 2006-07-01
DOI: 10.1111/j.1540-8167.2006.00509.x
卷: 17, 期:7, 页:771-775
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: RADIOFREQUENCY CATHETER ABLATION ; BUNDLE-BRANCH BLOCK ; PULMONARY-ARTERY ; ORIGIN ; SYSTEM
英文摘要:

Objective: To simulate right ventricular outflow tract tachycardia (RVOT-VT) in experimental animals.

Background: The mechanism(s) whereby a discrete area of myocardium in the RVOT becomes arrhythmogenic remains unknown.

Methods: In 13 dogs, a circular catheter was placed in the proximal pulmonary artery (PA) to contact the endovascular circumference of the PA. A 50-msec train of high-frequency stimulation (HFS, 200 Hz), coupled to atrial pacing, was applied at each bipolar pair of the circular catheter. The coupling interval was adjusted so that the 50-msec train occurred during the ventricular refractory period, that is, the QRS complex, in order to prevent stimulation of the myocardial sleeve within the proximal PA.

Results: In all dogs, HFS induced ventricular premature depolarizations and VTs with a left bundle branch block (LBBB) morphology and inferior axis (average 6.8 +/- 1.6 V). Earliest activation was consistently recorded from the proximal PA. Esmolol, a short-acting beta-blocker (1 mg/kg), was administered intravenously in 11 dogs. The inducible ventricular ectopy was abolished in 10 dogs (> 12 V, P < 0.05) and the response to HFS was blunted in one dog (10-11 V). After 30 minutes, the response to HFS returned to pre-esmolol levels.

Conclusions: Stimulation of the sympathetic input to the proximal PA induces ventricular ectopy and VTs exhibiting a left bundle branch block morphology and inferior axis, closely simulating clinical RVOT-VT. Beta-blockade either abolishes or blunts this response, corroborating the sympathetic etiology in this model and in some clinical cases of RVOT tachycardias.

语种: 英语
WOS记录号: WOS:000238395900016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53765
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
3.Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China

Recommended Citation:
Zhou, J,Scherlag, BJ,Yamanashi, W,et al. Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2006,17(7):771-775.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, J]'s Articles
[Scherlag, BJ]'s Articles
[Yamanashi, W]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, J]‘s Articles
[Scherlag, BJ]‘s Articles
[Yamanashi, W]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace