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学科主题: 临床医学
题名:
Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT
作者: Zhou, J; Scherlag, BJ; Yamanashi, W; Wu, R; Huang, Y; Lazzara, R; Jackman, WM; Po, SS
关键词: right ventricular outflow tract ; ventricular tachycardia ; sympathetic nerve ; autonomic nervous system ; ablation ; ventromedial cardiac nerve ; pulmonary artery
刊名: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
发表日期: 2006-07-01
DOI: 10.1111/j.1540-8167.2006.00509.x
卷: 17, 期:7, 页:771-775
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: RADIOFREQUENCY CATHETER ABLATION ; BUNDLE-BRANCH BLOCK ; PULMONARY-ARTERY ; ORIGIN ; SYSTEM
英文摘要:

Objective: To simulate right ventricular outflow tract tachycardia (RVOT-VT) in experimental animals.

Background: The mechanism(s) whereby a discrete area of myocardium in the RVOT becomes arrhythmogenic remains unknown.

Methods: In 13 dogs, a circular catheter was placed in the proximal pulmonary artery (PA) to contact the endovascular circumference of the PA. A 50-msec train of high-frequency stimulation (HFS, 200 Hz), coupled to atrial pacing, was applied at each bipolar pair of the circular catheter. The coupling interval was adjusted so that the 50-msec train occurred during the ventricular refractory period, that is, the QRS complex, in order to prevent stimulation of the myocardial sleeve within the proximal PA.

Results: In all dogs, HFS induced ventricular premature depolarizations and VTs with a left bundle branch block (LBBB) morphology and inferior axis (average 6.8 +/- 1.6 V). Earliest activation was consistently recorded from the proximal PA. Esmolol, a short-acting beta-blocker (1 mg/kg), was administered intravenously in 11 dogs. The inducible ventricular ectopy was abolished in 10 dogs (> 12 V, P < 0.05) and the response to HFS was blunted in one dog (10-11 V). After 30 minutes, the response to HFS returned to pre-esmolol levels.

Conclusions: Stimulation of the sympathetic input to the proximal PA induces ventricular ectopy and VTs exhibiting a left bundle branch block morphology and inferior axis, closely simulating clinical RVOT-VT. Beta-blockade either abolishes or blunts this response, corroborating the sympathetic etiology in this model and in some clinical cases of RVOT tachycardias.

语种: 英语
WOS记录号: WOS:000238395900016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53765
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
3.Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China

Recommended Citation:
Zhou, J,Scherlag, BJ,Yamanashi, W,et al. Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2006,17(7):771-775.
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