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学科主题: 临床医学
题名:
Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats
作者: Bai Yun-jing2; Jiang De-xun2; An Na2; Shen Hong-bo1; Hu Yin-qi3
关键词: Adjuvant arthritis model ; Vascular endothelial growth factor (VEGF) ; Interleukin-1 (IL-1) ; Environmental factors
刊名: JOURNAL OF TRADITIONAL CHINESE MEDICINE
发表日期: 2012-06-01
卷: 32, 期:2, 页:256-260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
英文摘要:

OBJECTIVE: To study the effects of environmental factors on the degree of injury and expression of vascular endothelial growth factor (VEGF) and interleukin-1 (IL-1) in cartilage cells of the joint in a rat model of adjuvant arthritis (AA).

METHODS: SD rats aged 10 months were randomly divided into 4 groups that varied by temperature and humidity housing conditions and induction of AA: a control group, a model group, a cold-damp group, and a hot-damp group. All groups except the control group were induced with AA. After 4 w, VEGF and IL-1 expression in cartilage cells of ankle joints of hind limbs were observed.

RESULTS: Mean area, optical density, and numbers of VEGF- and IL-1-positive cells in the model group, the cold-damp group, and the hot-damp group were significantly higher than that of the control group (all P<0.05). Optical density and positive cell numbers in the cold-damp group and the hot-damp group were significantly higher than that of the model group (all P<0.05). Optical density and positive cell numbers in the hot-damp group were significantly higher than that of the cold-damp group. Bone in the hot-damp and cold-damp groups was severely injured.

CONCLUSION: Environmental factors such as high humidity combined with either high or low temperature increase the severity of damage and expression of VEGF and IL-1 in cartilage cells of joints in rats induced with AA. (C) 2012 JTCM. All rights reserved.

语种: 英语
项目资助者: Shoufa Fund
WOS记录号: WOS:000304896400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53772
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Hosp 3, TCM Dept, Beijing 100191, Peoples R China
2.Gen Hosp Beijing Mil Reg, Rheumatism Dept, Beijing 100700, Peoples R China
3.China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China

Recommended Citation:
Bai Yun-jing,Jiang De-xun,An Na,et al. Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2012,32(2):256-260.
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