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Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats
Bai Yun-jing2; Jiang De-xun2; An Na2; Shen Hong-bo1; Hu Yin-qi3
关键词Adjuvant Arthritis Model Vascular Endothelial Growth Factor (Vegf) Interleukin-1 (Il-1) Environmental Factors
刊名JOURNAL OF TRADITIONAL CHINESE MEDICINE
2012-06-01
32期:2页:256-260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
英文摘要

OBJECTIVE: To study the effects of environmental factors on the degree of injury and expression of vascular endothelial growth factor (VEGF) and interleukin-1 (IL-1) in cartilage cells of the joint in a rat model of adjuvant arthritis (AA).

METHODS: SD rats aged 10 months were randomly divided into 4 groups that varied by temperature and humidity housing conditions and induction of AA: a control group, a model group, a cold-damp group, and a hot-damp group. All groups except the control group were induced with AA. After 4 w, VEGF and IL-1 expression in cartilage cells of ankle joints of hind limbs were observed.

RESULTS: Mean area, optical density, and numbers of VEGF- and IL-1-positive cells in the model group, the cold-damp group, and the hot-damp group were significantly higher than that of the control group (all P<0.05). Optical density and positive cell numbers in the cold-damp group and the hot-damp group were significantly higher than that of the model group (all P<0.05). Optical density and positive cell numbers in the hot-damp group were significantly higher than that of the cold-damp group. Bone in the hot-damp and cold-damp groups was severely injured.

CONCLUSION: Environmental factors such as high humidity combined with either high or low temperature increase the severity of damage and expression of VEGF and IL-1 in cartilage cells of joints in rats induced with AA. (C) 2012 JTCM. All rights reserved.

语种英语
WOS记录号WOS:000304896400021
资助机构Shoufa Fund
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53772
专题北京大学第三临床医学院
作者单位1.Beijing Univ, Hosp 3, TCM Dept, Beijing 100191, Peoples R China
2.Gen Hosp Beijing Mil Reg, Rheumatism Dept, Beijing 100700, Peoples R China
3.China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China
推荐引用方式
GB/T 7714
Bai Yun-jing,Jiang De-xun,An Na,et al. Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2012,32(2):256-260.
APA Bai Yun-jing,Jiang De-xun,An Na,Shen Hong-bo,&Hu Yin-qi.(2012).Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats.JOURNAL OF TRADITIONAL CHINESE MEDICINE,32(2),256-260.
MLA Bai Yun-jing,et al."Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats".JOURNAL OF TRADITIONAL CHINESE MEDICINE 32.2(2012):256-260.
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