IR@PKUHSC  > 北京大学精神卫生研究所
Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China
Li, You-Hong1,2; Xiang, Yu-Tao3,4; Su, Yun-Ai1,2; Shu, Liang1,2; Yu, Xin1,2; Kilbourne, Amy M.5,6; Ungvari, Gabor S.7,8; Chiu, Helen F. K.4; Ma, Cui9; Wang, Gao-Hua10; Bai, Pei-Shen11; Liu, Xie-He12; Sun, Li-Zhong13; Shi, Jian-Guo14; Chen, Xian-Sheng15; Mei, Qi-Yi16; Li, Ke-Qing17; Si, Tian-Mei1,2
关键词Benzodiazepines China Major Depressive Disorder Prescribing Patterns
收录类别SCI ; SSCI
WOS标题词Science & Technology
类目[WOS]Nursing ; Psychiatry
研究领域[WOS]Nursing ; Psychiatry

PURPOSE: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD.

DESIGN AND METHODS: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients′ socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form.

FINDINGS: A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors).

PRACTICE IMPLICATIONS: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use.

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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
作者单位1.Hebei Mental Hlth Ctr, Tangshan, Hebei Province, Peoples R China
2.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Vet Adm Ann Arbor Ctr Clin Management Res, Ann Arbor, MI USA
5.Hosp Psychiat, Guangzhou, Guangdong, Peoples R China
6.Neuropsychiat Hosp, Changchun, Jilin Province, Peoples R China
7.Mental Hlth Ctr, Xian, Shaanxi Provinc, Peoples R China
8.Jiangxi Psychiat Hosp, Nanchang, Jiangxi, Peoples R China
9.Suzhou Guangji Hosp, Suzhou, Jiangsu, Peoples R China
10.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
11.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
12.Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA
13.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
14.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
15.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430072, Hubei Province, Peoples R China
16.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi Province, Peoples R China
17.Sichuan Univ, West China Hosp, Chengdu 610064, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Li, You-Hong,Xiang, Yu-Tao,Su, Yun-Ai,et al. Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China[J]. PERSPECTIVES IN PSYCHIATRIC CARE,2014,50(3):149-154.
APA Li, You-Hong.,Xiang, Yu-Tao.,Su, Yun-Ai.,Shu, Liang.,Yu, Xin.,...&Si, Tian-Mei.(2014).Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China.PERSPECTIVES IN PSYCHIATRIC CARE,50(3),149-154.
MLA Li, You-Hong,et al."Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China".PERSPECTIVES IN PSYCHIATRIC CARE 50.3(2014):149-154.
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