IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
The cardiovascular effects of glucagon-like peptide-1 receptor agonists: a trial sequential analysis of randomized controlled trials
Wu, S.1; Sun, F.1; Zhang, Y.1; Yang, Z.1; Hong, T.2; Chen, Y.3; Zhan, S.1
关键词Cardiovascular Glp-1 Receptor Agonists Type 2 Diabetes
刊名JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
2014-02-01
DOI10.1111/jcpt.12102
39期:1页:7-13
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TYPE-2 DIABETES-MELLITUS ; CLINICAL-TRIALS ; MYOCARDIAL-INFARCTION ; INSULIN GLARGINE ; CARDIAC-FUNCTION ; GLYCEMIC CONTROL ; HEART-FAILURE ; METAANALYSIS ; EXENATIDE ; RISK
英文摘要

What is known and objective Glucagon-like peptide-1 (GLP-1) receptor agonists are a new class of antidiabetic drugs. Their wider use for the treatment of patients with type 2 diabetes mellitus has led to concerns about its cardiovascular effects. However, the robustness of data leading to those concerns is unclear. The purpose of this study is to systematically assess the robustness of the available evidence on the adverse cardiovascular effects of GLP-1 receptor agonists in patients with type 2 diabetes.

Methods The Cochrane library, MEDLINE, EMBASE and www.clinicaltrials.gov were searched from inception through to 25 January 2013. Randomized controlled trials (RCTs) were selected if they compared GLP-1 receptor agonists with placebo or other drugs with a duration 12weeks. Mantel-Haenszel odds ratio (MH-OR) of cardiovascular events with 95% confidence interval (CI) was estimated using a random effects model. Trial sequential analysis based on required information size with an assumption of plausible reductions in relative risk in the low-bias trials, 5% risk of a type I error and 20% risk of a type II error was used to explore the robustness of available evidence.

Results Fifty-eight trials were included in the analysis (10466 patients receiving GLP-1 receptor agonists and 7138 patients receiving comparators, respectively). Overall, the OR for cardiovascular events with GLP-1 receptor agonists was 052 (95% CI: 027-099) compared with placebo and 084 (95% CI: 052-136) with active controls. Trial sequential analyses showed that the actual accumulated sample size was only 11% (7445 of 65212) and 13% (10157 of 79198) of the required information size for placebo-controlled trials and active-controlled trials, respectively. These results indicate that there is still insufficient evidence on cardiovascular events.

What is new and conclusion GLP-1 receptor agonists do not seem to show any increased risk of cardiovascular events However, the available data from RCTs remain insufficient to confirm an absence of detrimental effect. More long-term trials and population-based studies are required to provide the necessary reassurance on the cardiovascular safety of GLP-1 receptor agonists.

语种英语
WOS记录号WOS:000329372100003
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53777
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Endocrinol & Metab, Beijing 100191, Peoples R China
3.Indiana Univ, Sch Med, Dept Publ Hlth, Indianapolis, IN USA
推荐引用方式
GB/T 7714
Wu, S.,Sun, F.,Zhang, Y.,et al. The cardiovascular effects of glucagon-like peptide-1 receptor agonists: a trial sequential analysis of randomized controlled trials[J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS,2014,39(1):7-13.
APA Wu, S..,Sun, F..,Zhang, Y..,Yang, Z..,Hong, T..,...&Zhan, S..(2014).The cardiovascular effects of glucagon-like peptide-1 receptor agonists: a trial sequential analysis of randomized controlled trials.JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS,39(1),7-13.
MLA Wu, S.,et al."The cardiovascular effects of glucagon-like peptide-1 receptor agonists: a trial sequential analysis of randomized controlled trials".JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 39.1(2014):7-13.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, S.]的文章
[Sun, F.]的文章
[Zhang, Y.]的文章
百度学术
百度学术中相似的文章
[Wu, S.]的文章
[Sun, F.]的文章
[Zhang, Y.]的文章
必应学术
必应学术中相似的文章
[Wu, S.]的文章
[Sun, F.]的文章
[Zhang, Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。