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学科主题: 临床医学
题名:
The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury
作者: Wang, Jin; Zhang, Peixun; Wang, Yanhua; Kou, Yuhui; Zhang, Hongbo; Jiang, Baoguo
关键词: nerve regeneration ; small gap ; bridging ; phenotype
刊名: ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
发表日期: 2010-02-01
DOI: 10.3109/10731190903495736
卷: 38, 期:1, 页:24-28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]: MYELINATION ; REGENERATION ; CONDUITS ; REPAIR ; TUBES
英文摘要:

To describe the phenotypic changes of Schwann cells during nerve regeneration, we made two different neurorrhaphy models after rat sciatic nerves injury, the epineurium neurorrhaphy and small gap bridging suture. Then, at selected time points after surgery (1d, 3d, 5d, 7d, 2 weeks, 3weeks), the materials were drawn for detecting the expression of GFAP, Sox2, Krox20 by immunofluorescence. GFAP is expressed in non-myelin-forming Schwann cells and Krox20 is a marker for myelin-forming cells in the adult nerve. Sox2 is a marker for neural stem and progenitor cells. Our findings showed the rule of phenotypic changes of Schwann cells during nerve regeneration. Furthermore, the difference in the phenotypic changes of Schwann cells between two operation methods indicated that the small gap changes the regenerated microenvironment and may be one of the reasons that small gap bridging suture is superior to the epineurium suture.

语种: 英语
所属项目编号: 30801169 ; 30801169
项目资助者: National Natural Science Fund ; China National Nature and Science Youth
WOS记录号: WOS:000273721100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53780
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Othoped, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Jin,Zhang, Peixun,Wang, Yanhua,et al. The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2010,38(1):24-28.
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