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The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury
Wang, Jin; Zhang, Peixun; Wang, Yanhua; Kou, Yuhui; Zhang, Hongbo; Jiang, Baoguo
关键词Nerve Regeneration Small Gap Bridging Phenotype
刊名ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
2010-02-01
DOI10.3109/10731190903495736
38期:1页:24-28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]MYELINATION ; REGENERATION ; CONDUITS ; REPAIR ; TUBES
英文摘要

To describe the phenotypic changes of Schwann cells during nerve regeneration, we made two different neurorrhaphy models after rat sciatic nerves injury, the epineurium neurorrhaphy and small gap bridging suture. Then, at selected time points after surgery (1d, 3d, 5d, 7d, 2 weeks, 3weeks), the materials were drawn for detecting the expression of GFAP, Sox2, Krox20 by immunofluorescence. GFAP is expressed in non-myelin-forming Schwann cells and Krox20 is a marker for myelin-forming cells in the adult nerve. Sox2 is a marker for neural stem and progenitor cells. Our findings showed the rule of phenotypic changes of Schwann cells during nerve regeneration. Furthermore, the difference in the phenotypic changes of Schwann cells between two operation methods indicated that the small gap changes the regenerated microenvironment and may be one of the reasons that small gap bridging suture is superior to the epineurium suture.

语种英语
WOS记录号WOS:000273721100005
项目编号30801169 ; 30801169
资助机构National Natural Science Fund ; China National Nature and Science Youth
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53780
专题北京大学第二临床医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Trauma & Othoped, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jin,Zhang, Peixun,Wang, Yanhua,et al. The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2010,38(1):24-28.
APA Wang, Jin,Zhang, Peixun,Wang, Yanhua,Kou, Yuhui,Zhang, Hongbo,&Jiang, Baoguo.(2010).The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury.ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,38(1),24-28.
MLA Wang, Jin,et al."The Observation of Phenotypic Changes of Schwann Cells after Rat Sciatic Nerve Injury".ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 38.1(2010):24-28.
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