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Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease
Chai, San Bao2; Li, Xue Min1; Pang, Yong Zheng3; Qi, Yong Fen3; Tang, Chao Shu3
关键词Endothelin-1 Urotensin-ii Coronary Heart Disease Percutaneous Transluminal Coronary Angioplasty
刊名HEART AND VESSELS
2010-03-01
DOI10.1007/s00380-009-1178-6
25期:2页:138-143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; ARTERY-DISEASE ; INCREASED EXPRESSION ; IMMUNOREACTIVITY ; FAILURE ; ATHEROSCLEROSIS ; ANGIOPLASTY ; CELLS
英文摘要

Research has identified the vasoconstrictors endothelin-1 (ET-1) and urotensin-II (U-II) as having a role in the development of atherosclerotic cardiovascular disease. We aimed to observe alterations in plasma levels of both ET-1 and U-II in patients with coronary heart disease (CHD) undergoing percutaneous transluminal coronary angioplasty (PTCA) and stent therapy from November 2006 through May 2007. We examined plasma levels of ET-1 and U-II in 40 patients with CHD and 40 age-matched healthy subjects by radioimmunoassay (RIA). Chi-square test, Student′s t-test, and one-way analysis of variance were used for statistical analyses. Correlations between variables were tested by simple linear regression analysis. Coronary heart disease patients had significantly higher ET-1 and UII levels than healthy controls (20.05 +/- 4.65 vs 8.16 +/- 3.38 and 71.90 +/- 11.61 vs 20.89 +/- 7.00 pg/ml, respectively, all P < 0.01). Importantly, plasma levels of U-II and ET-1 were correlated in patients with CHD (r = 0.64, P = 0.01). On day 1 after PTCA and stent therapy, plasma levels of ET-1 and U-II were significantly higher, by 99% and 25%, respectively, than those before therapy (all P < 0.01). On day 3 after therapy, ET-1 levels were higher by 25% (P < 0.01) than before therapy, and U-II levels decreased rapidly and were close to baseline levels (P > 0.05). On day 7 after therapy, CHD patients had significantly lower ET-1 and U-II levels than before therapy (all P < 0.01). Since ET-1 and U-II levels may be increased in plasma of patients with CHD, their activation might have clinical significance in terms of early intervention in patients with CHD, especially after PTCA and stent therapy.

语种英语
WOS记录号WOS:000276049700010
项目编号2006CB503807
资助机构Major State Basic Research Development Program of the People&prime ; s Republic of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53782
专题北京大学第三临床医学院_眼科
作者单位1.Beijing Fengtai Hosp, Dept Cardiovasc Dis, Beijing, Peoples R China
2.Beijing Univ, Dept Ophthalmol, Ctr Eye, Beijing 100083, Peoples R China
3.Peking Univ, Inst Cardiovasc Dis, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chai, San Bao,Li, Xue Min,Pang, Yong Zheng,et al. Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease[J]. HEART AND VESSELS,2010,25(2):138-143.
APA Chai, San Bao,Li, Xue Min,Pang, Yong Zheng,Qi, Yong Fen,&Tang, Chao Shu.(2010).Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease.HEART AND VESSELS,25(2),138-143.
MLA Chai, San Bao,et al."Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease".HEART AND VESSELS 25.2(2010):138-143.
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