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学科主题: 临床医学
题名:
Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease
作者: Chai, San Bao2; Li, Xue Min1; Pang, Yong Zheng3; Qi, Yong Fen3; Tang, Chao Shu3
关键词: Endothelin-1 ; Urotensin-II ; Coronary heart disease ; Percutaneous transluminal coronary angioplasty
刊名: HEART AND VESSELS
发表日期: 2010-03-01
DOI: 10.1007/s00380-009-1178-6
卷: 25, 期:2, 页:138-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; ARTERY-DISEASE ; INCREASED EXPRESSION ; IMMUNOREACTIVITY ; FAILURE ; ATHEROSCLEROSIS ; ANGIOPLASTY ; CELLS
英文摘要:

Research has identified the vasoconstrictors endothelin-1 (ET-1) and urotensin-II (U-II) as having a role in the development of atherosclerotic cardiovascular disease. We aimed to observe alterations in plasma levels of both ET-1 and U-II in patients with coronary heart disease (CHD) undergoing percutaneous transluminal coronary angioplasty (PTCA) and stent therapy from November 2006 through May 2007. We examined plasma levels of ET-1 and U-II in 40 patients with CHD and 40 age-matched healthy subjects by radioimmunoassay (RIA). Chi-square test, Student′s t-test, and one-way analysis of variance were used for statistical analyses. Correlations between variables were tested by simple linear regression analysis. Coronary heart disease patients had significantly higher ET-1 and UII levels than healthy controls (20.05 +/- 4.65 vs 8.16 +/- 3.38 and 71.90 +/- 11.61 vs 20.89 +/- 7.00 pg/ml, respectively, all P < 0.01). Importantly, plasma levels of U-II and ET-1 were correlated in patients with CHD (r = 0.64, P = 0.01). On day 1 after PTCA and stent therapy, plasma levels of ET-1 and U-II were significantly higher, by 99% and 25%, respectively, than those before therapy (all P < 0.01). On day 3 after therapy, ET-1 levels were higher by 25% (P < 0.01) than before therapy, and U-II levels decreased rapidly and were close to baseline levels (P > 0.05). On day 7 after therapy, CHD patients had significantly lower ET-1 and U-II levels than before therapy (all P < 0.01). Since ET-1 and U-II levels may be increased in plasma of patients with CHD, their activation might have clinical significance in terms of early intervention in patients with CHD, especially after PTCA and stent therapy.

语种: 英语
所属项目编号: 2006CB503807
项目资助者: Major State Basic Research Development Program of the People&prime ; s Republic of China
WOS记录号: WOS:000276049700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53782
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Beijing Fengtai Hosp, Dept Cardiovasc Dis, Beijing, Peoples R China
2.Beijing Univ, Dept Ophthalmol, Ctr Eye, Beijing 100083, Peoples R China
3.Peking Univ, Inst Cardiovasc Dis, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Chai, San Bao,Li, Xue Min,Pang, Yong Zheng,et al. Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease[J]. HEART AND VESSELS,2010,25(2):138-143.
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