IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells
Kim, TJ; Zhang, YH; Kim, YS; Lee, CK; Lee, MK; Hong, JT; Yun, YP
关键词Apigenin Vascular Smooth Muscle Cell Cell Proliferation Map Kinase C-fos
刊名PLANTA MEDICA
2002-07-01
68期:7页:605-609
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]TRANSDUCTION PATHWAY ; FLAVONOIDS ; KINASE ; ATHEROSCLEROSIS ; PATHOGENESIS ; INHIBITION ; EXPRESSION ; TISSUES ; BETA
英文摘要

The inhibitory effects of apigenin on the growth factor-induced proliferative responses, and expression of mitogen-activated protein (MAP) kinase and its downstream c-fos in rat aortic vascular smooth muscle cells (VSMCs) were investigated. Apigenin significantly inhibited both 5% fetal bovine serum (FBS)- and 50 ng/mL platelet derived growth factor-BB (PDGF-BB)-induced proliferation on primary cultured rat VSMCs in a concentration-dependent manner. In addition, apigenin resulted in a significant inhibition of the FBS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and expression of c-fos mRNA. These results suggest that apigenin inhibits FBS- and PDGF-BB-induced VSMC proliferation, and its activity may be mediated, at least in part, by down regulation of ERK 1/2 and its downstream c-fos mRNA.

语种英语
WOS记录号WOS:000177106100006
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53783
专题北京大学基础医学院_药理学系
作者单位1.Chungbuk Natl Univ, Coll Pharm, Heungduk Gu 361763, Cheongju, South Korea
2.Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju, South Korea
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Kim, TJ,Zhang, YH,Kim, YS,et al. Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells[J]. PLANTA MEDICA,2002,68(7):605-609.
APA Kim, TJ.,Zhang, YH.,Kim, YS.,Lee, CK.,Lee, MK.,...&Yun, YP.(2002).Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells.PLANTA MEDICA,68(7),605-609.
MLA Kim, TJ,et al."Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells".PLANTA MEDICA 68.7(2002):605-609.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Effects of apigenin (209KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Kim, TJ]的文章
[Zhang, YH]的文章
[Kim, YS]的文章
百度学术
百度学术中相似的文章
[Kim, TJ]的文章
[Zhang, YH]的文章
[Kim, YS]的文章
必应学术
必应学术中相似的文章
[Kim, TJ]的文章
[Zhang, YH]的文章
[Kim, YS]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。