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学科主题: 基础医学
题名:
Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells
作者: Kim, TJ; Zhang, YH; Kim, YS; Lee, CK; Lee, MK; Hong, JT; Yun, YP
关键词: apigenin ; vascular smooth muscle cell ; cell proliferation ; MAP kinase ; c-fos
刊名: PLANTA MEDICA
发表日期: 2002-07-01
卷: 68, 期:7, 页:605-609
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: TRANSDUCTION PATHWAY ; FLAVONOIDS ; KINASE ; ATHEROSCLEROSIS ; PATHOGENESIS ; INHIBITION ; EXPRESSION ; TISSUES ; BETA
英文摘要:

The inhibitory effects of apigenin on the growth factor-induced proliferative responses, and expression of mitogen-activated protein (MAP) kinase and its downstream c-fos in rat aortic vascular smooth muscle cells (VSMCs) were investigated. Apigenin significantly inhibited both 5% fetal bovine serum (FBS)- and 50 ng/mL platelet derived growth factor-BB (PDGF-BB)-induced proliferation on primary cultured rat VSMCs in a concentration-dependent manner. In addition, apigenin resulted in a significant inhibition of the FBS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and expression of c-fos mRNA. These results suggest that apigenin inhibits FBS- and PDGF-BB-induced VSMC proliferation, and its activity may be mediated, at least in part, by down regulation of ERK 1/2 and its downstream c-fos mRNA.

语种: 英语
WOS记录号: WOS:000177106100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53783
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Chungbuk Natl Univ, Coll Pharm, Heungduk Gu 361763, Cheongju, South Korea
2.Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju, South Korea
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China

Recommended Citation:
Kim, TJ,Zhang, YH,Kim, YS,et al. Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells[J]. PLANTA MEDICA,2002,68(7):605-609.
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