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The Association between Subclinical Atherosclerosis and Uterine Fibroids
He, Yuan1,2; Zeng, Qiang1; Li, Xiaohui1; Liu, Baohua3; Wang, Peiyu3
刊名PLOS ONE
2013-02-22
DOI10.1371/journal.pone.0057089
8期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者state science and technology support program ; Institutional Review Board of the PLA General Hospital ; state science and technology support program ; Institutional Review Board of the PLA General Hospital
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]C-REACTIVE PROTEIN ; PREMENOPAUSAL WOMEN ; BREAST-CANCER ; BODY-SIZE ; PLASMA HOMOCYSTEINE ; RISK-FACTORS ; BLACK-WOMEN ; LEIOMYOMA ; HYPERTENSION ; ETIOLOGY
英文摘要

Objective(s): To explore the atherogenic hypothesis of uterine fibroids among Chinese women.

Methods: In a case-control study, 335 patients confirmed by ultrasound or hysterectomy surgery and 539 controls were enrolled between October 1, 2009 and April 1, 2012. Unconditional logistic regressions were used to calculate the odds ratios (ORs) for the associations of subclinical atherogenic and cardiovascular risk parameters with uterine fibroids in the overall case group and hysterectomy-confirmed case group, respectively.

Results: Higher level of ankle-brachial index (ABI) was independently associated with increased odds of uterine fibroids. The odds of UF among women in the highest tertile of ABI were 1.88 times higher (95%CI: 1.17, 3.02, P-trend = 0.008) compared to those in the lowest tertile. The serum concentration of homocysteine was inversely related to fibroids (middle vs. low: OR 0.56, 95%CI: 0.36, 0.85; high vs. low: OR 0.50, 95% CI: 0.32, 0.79; P-trend = 0.002). In the hysterectomy-confirmed group, an inverse association was suggested between high-density lipoprotein cholesterol (HDL-C) and fibroids (OR 0.46, 95% CI: 0.25, 0.84, P-trend = 0.014). Moreover, the effect of homocysteine concentration was not observed in this group.

Conclusion(s): These findings suggest that women with uterine fibroids might have an increased risk of subclinical atherosclerosis.

语种英语
所属项目编号2012BAI37B04
资助者state science and technology support program ; Institutional Review Board of the PLA General Hospital ; state science and technology support program ; Institutional Review Board of the PLA General Hospital
WOS记录号WOS:000316658800072
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53787
专题北京大学公共卫生学院
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Int Med Ctr, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
He, Yuan,Zeng, Qiang,Li, Xiaohui,et al. The Association between Subclinical Atherosclerosis and Uterine Fibroids[J]. PLOS ONE,2013,8(2).
APA He, Yuan,Zeng, Qiang,Li, Xiaohui,Liu, Baohua,&Wang, Peiyu.(2013).The Association between Subclinical Atherosclerosis and Uterine Fibroids.PLOS ONE,8(2).
MLA He, Yuan,et al."The Association between Subclinical Atherosclerosis and Uterine Fibroids".PLOS ONE 8.2(2013).
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