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学科主题: 临床医学
题名:
Comparative study of the efficacy and safety between blonanserin and risperidone for the treatment of schizophrenia in Chinese patients: A double-blind, parallel-group multicenter randomized trial
作者: Li, Huafang1; Yao, Chen2; Shi, Jianguo3; Yang, Fude4; Qi, Shuguang5; Wang, Lili6; Zhang, Honggeng7; Li, Jie8; Wang, Chuanyue9; Wang, Chuansheng10; Liu, Cui11; Li, Lehua12; Wang, Qiang13; Li, Keqing14; Luo, Xiaoyan15; Gu, Niufan1
关键词: Antipsychotic agents ; Blonanserin ; Randomized controlled trial ; Risperidone ; Schizophrenia
刊名: JOURNAL OF PSYCHIATRIC RESEARCH
发表日期: 2015-10-01
DOI: 10.1016/j.jpsychires.2015.07.015
卷: 69, 页:102-109
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
英文摘要:

This randomized, double-blind study compared the efficacy and safety of blonanserin and risperidone to treat Chinese schizophrenia patients aged >= 18 and < 65 years. Patients with Positive and Negative Syndrome Scale (PANSS) total scores >= 70 and <= 120 were randomized to receive blonanserin or risperidone using a gradual dose-titration method (blonanserin tablets: 8-24 mg/day; risperidone tablets: 2-6 mg/day), twice daily. Treatment populations consisted of 128 blonanserin-treated patients and 133 risperidone-treated patients. Intention-to-treat analysis was performed using the last observation carried forward method. Reductions of PANSS total scores by blonanserin and risperidone treatment were -30.59 and -33.56, respectively. Risperidone treatment was associated with elevated levels of serum prolactin (67.16% risperidone versus 5231% blonanserin) and cardiac-related abnormalities (2239% risperidone versus 12.31% blonanserin), and blonanserin patients were more prone to extrapyramidal side effects (48.46% blonanserin versus 29.10% risperidone). In conclusion, blonanserin was as effective as risperidone for the treatment of Chinese patients with schizophrenia. The overall safety profiles of these drugs are comparable, although blonanserin was associated with a higher incidence of EPS and risperidone was associated with a higher incidence of prolactin elevation and weight gain. Thus, blonanserin is useful for the treatment of Chinese schizophrenia patients. (C) 2015 The Authors. Published by Elsevier Ltd.

语种: 英语
项目资助者: Sumitomo Pharmaceutical (Suzhou) Co., Ltd.
WOS记录号: WOS:000361927800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53793
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.Tianjin Anding Hosp, Dept Psychiat, Tianjin 300222, Peoples R China
2.Henan Prov Mental Hosp, Dept Psychiat, Xinxiang 453002, Peoples R China
3.Hebei Mental Hlth Ctr, Dept Psychiat, Baoding 071000, Peoples R China
4.Sumitomo Pharma Suzhou Co Ltd, Div Med, Beijing 100007, Peoples R China
5.Wuxi Mental Hlth Ctr, Dept Psychiat, Wuxi 214000, Peoples R China
6.Peking Univ, Clin Res Inst, Beijing 100191, Peoples R China
7.Xian Mental Hlth Ctr, Dept Psychiat, Xian 710061, Peoples R China
8.Beijing Huilongguan Hosp, Dept Psychiat, Beijing 100096, Peoples R China
9.Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai 200030, Peoples R China
10.Brains Hosp Hunan Prov, Dept Psychiat, Changsha 410007, Hunan, Peoples R China
11.Guangzhou Brain Hosp, Dept Psychiat, Guangzhou 510370, Guangdong, Peoples R China
12.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing 100088, Peoples R China
13.Peking Univ, Hosp 6, Dept Psychiat, Beijing 100191, Peoples R China
14.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410000, Hunan, Peoples R China
15.Sichuan Univ, West China Hosp, Dept Psychiat, Chengdu 610041, Peoples R China

Recommended Citation:
Li, Huafang,Yao, Chen,Shi, Jianguo,et al. Comparative study of the efficacy and safety between blonanserin and risperidone for the treatment of schizophrenia in Chinese patients: A double-blind, parallel-group multicenter randomized trial[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,69:102-109.
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