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学科主题临床医学
A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils
Liu, Xiaoyu1,2; Wang, Lizhen1,2; Ji, Jing1,2; Yao, Wei3; Wei, Wei4; Fan, Jie1,2; Joshi, Shailesh3; Li, Deyu1,2; Fan, Yubo1,2,5
关键词Fibril Crimping Morphology Constitutive Model Corneal Mechanical Properties
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2014-04-01
DOI10.1167/iovs.13-12633
55期:4页:2739-2746
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Sino-UK Higher Education ; National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Sino-UK Higher Education
研究领域[WOS]Ophthalmology
关键词[WOS]X-RAY-DIFFRACTION ; BIOMECHANICAL PROPERTIES ; PORCINE CORNEA ; STROMAL MICROSTRUCTURE ; EX-VIVO ; ORIENTATION ; ORGANIZATION ; TISSUES ; BOVINE ; TENDON
英文摘要

PURPOSE. To develop a mechanical model with which to investigate the relationship between the crimping morphology of collagen fibrils and the nonlinear mechanical behavior of the cornea.

METHODS. Uniaxial tensile experiments were performed with corneal strips to test their mechanical behavior. A constitutive model was constructed based on the Gaussian-distributed morphology of crimped collagen fibrils. The parameters that represent the micro characteristics of collagen fibrils were determined by fitting the experimental data to the constitutive model. Transmission electron microscopy (TEM) was used to visualize the crimping morphology of collagen fibrils in the stroma. A quantitative analysis of fibril crimping degrees in the TEM images was conducted to test the parameters predicted by the constitutive model.

RESULTS. The parameters were derived using a fitting method that included the expectation for the distribution of fibril crimping degrees, mu = 1.063; the standard deviation, sigma = 0.0781; the elastic modulus of collagen fibrils, E = 52.74 MPa; and the fibril ultimate strain, epsilon(b) = 0.1957. TEM images showed a variation of the fibril crimping morphology when the cornea was subjected to different tensile loads. A good agreement was found between the parameters derived by the constitutive model and the data quantified from the TEM images.

CONCLUSIONS. The nonlinear mechanical behavior of the cornea is closely correlated with the crimping morphology of collagen fibrils. The findings are expected to guide further research of corneal pathologies related to the abnormal microstructure of collagen fibrils.

语种英语
所属项目编号11120101001 ; 11202017 ; 2011CB710901
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Sino-UK Higher Education ; National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Sino-UK Higher Education
WOS记录号WOS:000335913100096
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53800
Collection北京大学第三临床医学院_眼科
作者单位1.Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R China
2.Beihang Univ, Minist Sci & Technol China, Int Joint Res Ctr Aerosp Biotechnol & Med Engn, Beijing 100191, Peoples R China
3.Univ Strathclyde, Dept Biomed Engn, Bioengn Unit, Glasgow, Lanark, Scotland
4.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100871, Peoples R China
5.Beihang Univ, State Key Lab Virtual Real Technol & Syst, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiaoyu,Wang, Lizhen,Ji, Jing,et al. A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2014,55(4):2739-2746.
APA Liu, Xiaoyu.,Wang, Lizhen.,Ji, Jing.,Yao, Wei.,Wei, Wei.,...&Fan, Yubo.(2014).A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,55(4),2739-2746.
MLA Liu, Xiaoyu,et al."A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55.4(2014):2739-2746.
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