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学科主题: 临床医学
题名:
A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils
作者: Liu, Xiaoyu1,2; Wang, Lizhen1,2; Ji, Jing1,2; Yao, Wei3; Wei, Wei4; Fan, Jie1,2; Joshi, Shailesh3; Li, Deyu1,2; Fan, Yubo1,2,5
关键词: fibril crimping morphology ; constitutive model ; corneal mechanical properties
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2014-04-01
DOI: 10.1167/iovs.13-12633
卷: 55, 期:4, 页:2739-2746
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: X-RAY-DIFFRACTION ; BIOMECHANICAL PROPERTIES ; PORCINE CORNEA ; STROMAL MICROSTRUCTURE ; EX-VIVO ; ORIENTATION ; ORGANIZATION ; TISSUES ; BOVINE ; TENDON
英文摘要:

PURPOSE. To develop a mechanical model with which to investigate the relationship between the crimping morphology of collagen fibrils and the nonlinear mechanical behavior of the cornea.

METHODS. Uniaxial tensile experiments were performed with corneal strips to test their mechanical behavior. A constitutive model was constructed based on the Gaussian-distributed morphology of crimped collagen fibrils. The parameters that represent the micro characteristics of collagen fibrils were determined by fitting the experimental data to the constitutive model. Transmission electron microscopy (TEM) was used to visualize the crimping morphology of collagen fibrils in the stroma. A quantitative analysis of fibril crimping degrees in the TEM images was conducted to test the parameters predicted by the constitutive model.

RESULTS. The parameters were derived using a fitting method that included the expectation for the distribution of fibril crimping degrees, mu = 1.063; the standard deviation, sigma = 0.0781; the elastic modulus of collagen fibrils, E = 52.74 MPa; and the fibril ultimate strain, epsilon(b) = 0.1957. TEM images showed a variation of the fibril crimping morphology when the cornea was subjected to different tensile loads. A good agreement was found between the parameters derived by the constitutive model and the data quantified from the TEM images.

CONCLUSIONS. The nonlinear mechanical behavior of the cornea is closely correlated with the crimping morphology of collagen fibrils. The findings are expected to guide further research of corneal pathologies related to the abnormal microstructure of collagen fibrils.

语种: 英语
所属项目编号: 11120101001 ; 11202017 ; 2011CB710901
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Sino-UK Higher Education
WOS记录号: WOS:000335913100096
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53800
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R China
2.Beihang Univ, Minist Sci & Technol China, Int Joint Res Ctr Aerosp Biotechnol & Med Engn, Beijing 100191, Peoples R China
3.Univ Strathclyde, Dept Biomed Engn, Bioengn Unit, Glasgow, Lanark, Scotland
4.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100871, Peoples R China
5.Beihang Univ, State Key Lab Virtual Real Technol & Syst, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Xiaoyu,Wang, Lizhen,Ji, Jing,et al. A Mechanical Model of the Cornea Considering the Crimping Morphology of Collagen Fibrils[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2014,55(4):2739-2746.
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