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学科主题: 药学
题名:
Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes
作者: He, Jing-Yu1; Zhu, Shu1; Goda, Yukihiro2; Cai, Shao-Qing3; Komatsu, Katsuko1
关键词: Codonopsis ; Quantitative analysis ; Alkaloids ; Phenylpropanoid ; Polyacetylenes
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2014-04-01
DOI: 10.1007/s11418-013-0801-0
卷: 68, 期:2, 页:326-339
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: LOBELIA-INFLATA ; TANGSHEN OLIV ; DERIVATIVES ; LOBETYOLIN ; ROOTS
英文摘要:

A comparative study of 56 specimens of three medicinally-used Codonopsis taxa collected from China and 54 commercial samples of Codonopsis Radix available in Chinese, Japanese and Korean markets was carried out by quantitative analysis of seven major components: codonopyrrolidium B (1), codonopyrrolidium A (2), tangshenoside I (3), cordifolioidyne B (4), lobetyolinin (5), lobetyolin (6) and lobetyol (7). The quantitative results, based on a well-established HPLC-DAD method, indicated that the contents of these seven compounds varied considerably among the samples, not only inter-species but also intra-species. C. pilosula and C. pilosula var. modesta showed similar chemical compositions, while C. tangshen differed considerably from these two in chemical composition. The results of principal component analysis (PCA) indicated that two main groups were classified; one group mainly included C. pilosula, C. pilosula var. modesta and the commercial samples derived from these two taxa, while the other group was composed of C. tangshen and its derived commercial samples. Compound 1 was the main component in the roots of C. pilosula and C. pilosula var. modesta, while 3 and 2 had relatively high contents in the roots of C. tangshen. Therefore, 3, 2 and 1 could be chemical markers to differentiate C. tangshen from C. pilosula and C. pilosula var. modesta.

语种: 英语
所属项目编号: 21406004 ; 24406005 ; KHB1008
项目资助者: JSPS ; Japan Health Sciences Foundation ; MEXT, Japan
WOS记录号: WOS:000332826900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53810
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Toyama Univ, Inst Nat Med, Div Pharmacognosy, Dept Med Resources, Toyama 9300194, Japan
2.Natl Inst Hlth Sci, Div Pharmacognosy Phytochem & Narcot, Setagaya Ku, Tokyo 1588501, Japan
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
He, Jing-Yu,Zhu, Shu,Goda, Yukihiro,et al. Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes[J]. JOURNAL OF NATURAL MEDICINES,2014,68(2):326-339.
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