IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells
Chen, Shanwen; Zhu, Jing; Zuo, Shuai; Ma, Ju; Zhang, Junling; Chen, Guowei; Wang, Xin; Pan, Yisheng; Liu, Yucun; Wang, Pengyuan
关键词Colon Cancer 1 Emt 25(Oh)2d3 Vdr Sw-480 Ht-29
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-12-04
DOI10.1016/j.bbrc.2015.10.146
468期:1-2页:130-135
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]VITAMIN-D ANALOG ; N-CADHERIN ; 1-ALPHA,25-DIHYDROXYVITAMIN D-3 ; COLORECTAL-CANCER ; TUMOR PROGRESSION ; CARCINOMA-CELLS ; IN-VITRO ; TGF-BETA ; EXPRESSION ; ADHESION
英文摘要

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) has been reported to inhibit proliferation and migration of multiple types of cancer cells. However, the mechanism underlying its anti-metastasis effect is not fully illustrated. In this study, the effect of 1,25(OH)2D3 on TGF-beta 1/beta 2-induced epithelial mesenchymal transition (EMT) is tested in colon cancer cells. The results suggest that 1,25(OH)2D3 inhibited TGF-beta 1/beta 2-induced increased invasion and migration of in SW-480 and HT-29 cells. 1,25(OH)2D3 also inhibited the cadherin switch in SW-480 and HT-29 cells. TGF-beta 1/beta 2-induced increased expression of EMT-related transcription factors was also inhibited by 1,25(OH)2D3. 1,25(OH)2D3 also inhibited the secretion of MMP-2 and MMP-9 and increased expression of F-actin induced by TGF-beta 1/beta 2 in SW-480 cells. Taken together, this study suggests that the suppression of EMT might be one of the mechanisms underlying the anti-metastasis effect of 1,25(OH)2D3 in colon cancer cells. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000366240800021
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53812
专题北京大学第一临床医学院
北京大学第一临床医学院_普通外科
作者单位Peking Univ, Hosp 1, Div Gen Surg, Beijing 100034, Peoples R China
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GB/T 7714
Chen, Shanwen,Zhu, Jing,Zuo, Shuai,et al. 1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,468(1-2):130-135.
APA Chen, Shanwen.,Zhu, Jing.,Zuo, Shuai.,Ma, Ju.,Zhang, Junling.,...&Wang, Pengyuan.(2015).1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,468(1-2),130-135.
MLA Chen, Shanwen,et al."1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 468.1-2(2015):130-135.
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