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学科主题: 临床医学
题名:
1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells
作者: Chen, Shanwen; Zhu, Jing; Zuo, Shuai; Ma, Ju; Zhang, Junling; Chen, Guowei; Wang, Xin; Pan, Yisheng; Liu, Yucun; Wang, Pengyuan
关键词: 1,25(OH)2D3 ; Colon cancer ; EMT ; VDR ; SW-480 ; HT-29
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2015-12-04
DOI: 10.1016/j.bbrc.2015.10.146
卷: 468, 期:1-2, 页:130-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: VITAMIN-D ANALOG ; N-CADHERIN ; 1-ALPHA,25-DIHYDROXYVITAMIN D-3 ; COLORECTAL-CANCER ; TUMOR PROGRESSION ; CARCINOMA-CELLS ; IN-VITRO ; TGF-BETA ; EXPRESSION ; ADHESION
英文摘要:

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) has been reported to inhibit proliferation and migration of multiple types of cancer cells. However, the mechanism underlying its anti-metastasis effect is not fully illustrated. In this study, the effect of 1,25(OH)2D3 on TGF-beta 1/beta 2-induced epithelial mesenchymal transition (EMT) is tested in colon cancer cells. The results suggest that 1,25(OH)2D3 inhibited TGF-beta 1/beta 2-induced increased invasion and migration of in SW-480 and HT-29 cells. 1,25(OH)2D3 also inhibited the cadherin switch in SW-480 and HT-29 cells. TGF-beta 1/beta 2-induced increased expression of EMT-related transcription factors was also inhibited by 1,25(OH)2D3. 1,25(OH)2D3 also inhibited the secretion of MMP-2 and MMP-9 and increased expression of F-actin induced by TGF-beta 1/beta 2 in SW-480 cells. Taken together, this study suggests that the suppression of EMT might be one of the mechanisms underlying the anti-metastasis effect of 1,25(OH)2D3 in colon cancer cells. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000366240800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53812
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Div Gen Surg, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Shanwen,Zhu, Jing,Zuo, Shuai,et al. 1,25(OH)2D3 attenuates TGF-beta 1/beta 2-induced increased migration and invasion via inhibiting epithelial-mesenchymal transition in colon cancer cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,468(1-2):130-135.
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