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学科主题: 药学
题名:
New triterpenoids from Kadsura heteroclita and their cytotoxic activity
作者: Wang, W; Liu, JZ; Han, J; Xu, ZR; Liu, RX; Liu, P; Wang, WX; Ma, XC; Guan, SH; Guo, D
关键词: Kadsura heteroclita ; Schizandraceae ; triterpenoids ; cytotoxic activity ; cyclolanostane ; lactone
刊名: PLANTA MEDICA
发表日期: 2006-04-01
DOI: 10.1055/s-2005-916263
卷: 72, 期:5, 页:450-457
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: SCHISANDRA SP ; ACID ; LACTONES ; LIGNANS
英文摘要:

Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A - E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time from a natural source, and the six known compounds schisanlactone E (8), cycloartenone (9), schisandronic acid (10), nigranoic acid (11), changnanic acid (12) and schisanlactone B (13), respectively. The structures of these compounds were characterized by extensive 1D and 2D NMR spectral analyses. The majority of these triterpenoids showed moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL60. Among the compounds tested, heteroclitalactone D (4) showed the strongest cytotoxic activity against the HL-60 cells with an IC50 of 6.76 mu M.

语种: 英语
WOS记录号: WOS:000237192200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53826
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai, Peoples R China

Recommended Citation:
Wang, W,Liu, JZ,Han, J,et al. New triterpenoids from Kadsura heteroclita and their cytotoxic activity[J]. PLANTA MEDICA,2006,72(5):450-457.
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