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New triterpenoids from Kadsura heteroclita and their cytotoxic activity
Wang, W; Liu, JZ; Han, J; Xu, ZR; Liu, RX; Liu, P; Wang, WX; Ma, XC; Guan, SH; Guo, D
关键词Kadsura Heteroclita Schizandraceae Triterpenoids Cytotoxic Activity Cyclolanostane Lactone
刊名PLANTA MEDICA
2006-04-01
DOI10.1055/s-2005-916263
72期:5页:450-457
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]SCHISANDRA SP ; ACID ; LACTONES ; LIGNANS
英文摘要

Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A - E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time from a natural source, and the six known compounds schisanlactone E (8), cycloartenone (9), schisandronic acid (10), nigranoic acid (11), changnanic acid (12) and schisanlactone B (13), respectively. The structures of these compounds were characterized by extensive 1D and 2D NMR spectral analyses. The majority of these triterpenoids showed moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL60. Among the compounds tested, heteroclitalactone D (4) showed the strongest cytotoxic activity against the HL-60 cells with an IC50 of 6.76 mu M.

语种英语
WOS记录号WOS:000237192200011
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53826
Collection北京大学药学院
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Wang, W,Liu, JZ,Han, J,et al. New triterpenoids from Kadsura heteroclita and their cytotoxic activity[J]. PLANTA MEDICA,2006,72(5):450-457.
APA Wang, W.,Liu, JZ.,Han, J.,Xu, ZR.,Liu, RX.,...&Guo, D.(2006).New triterpenoids from Kadsura heteroclita and their cytotoxic activity.PLANTA MEDICA,72(5),450-457.
MLA Wang, W,et al."New triterpenoids from Kadsura heteroclita and their cytotoxic activity".PLANTA MEDICA 72.5(2006):450-457.
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