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Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin
Li, Caiyun1; Zhang, Dianrui1; Guo, Hejian1; Hao, Leilei1; Zheng, Dandan1; Liu, Guangpu1; Shen, Jingyi1; Tian, Xiaona1; Zhang, Qiang2
关键词Oridonin Galactosylated Bovine Serum Albumin Nanoparticles Liver Targeting
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2013-05-01
DOI10.1016/j.ijpharm.2013.03.019
448期:1页:79-86
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PROTEIN NANOPARTICLES ; CELLS ; OPTIMIZATION ; SUGARS
英文摘要

In this study, galactosylated bovine serum albumin (GB), which could be developed for a liver targeting carrier was synthetized and it was identified by Fourier transform infrared (FT-IR) spectrometer. Oridonin loaded bovine serum albumin nanoparticle (ORI-BSA-NP) and oridonin loaded GB nanoparticle (ORI-GB-NP) were prepared and optimized by the desolvation technique. During the preparation of ORI-GB-NP, galactosamine was introduced to end-cap the free aldehyde groups on nanoparticles. The characteristics of ORI-GB-NP such as particle size, zeta potential, particle morphologie, entrapment efficiency and drug loading were evaluated. The nearly spherical nanoparticles, with a narrow size distribution below 200 nm, were negatively charged with zeta potential of about -30 mV. Meanwhile, differential scanning calorimetry (DSC) and X-ray diffraction confirmed the amorphous state of ORI in ORI-GB-NP. The in vitro drug release of ORI from ORI-GB-NP presented a biphasic pattern with an initial burst effect and consequently sustained release. These results implied that the nanoparticles possessed fine physicochemical characteristics and seemed to be a stable delivery system for poorly soluble oridonin. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2009CB930300
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000319052000009
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53828
Collection北京大学药学院
作者单位1.Shandong Univ, Coll Pharm, Jinan 250100, Shandong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Caiyun,Zhang, Dianrui,Guo, Hejian,et al. Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,448(1):79-86.
APA Li, Caiyun.,Zhang, Dianrui.,Guo, Hejian.,Hao, Leilei.,Zheng, Dandan.,...&Zhang, Qiang.(2013).Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin.INTERNATIONAL JOURNAL OF PHARMACEUTICS,448(1),79-86.
MLA Li, Caiyun,et al."Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin".INTERNATIONAL JOURNAL OF PHARMACEUTICS 448.1(2013):79-86.
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