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学科主题: 药学
题名:
Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin
作者: Li, Caiyun1; Zhang, Dianrui1; Guo, Hejian1; Hao, Leilei1; Zheng, Dandan1; Liu, Guangpu1; Shen, Jingyi1; Tian, Xiaona1; Zhang, Qiang2
关键词: Oridonin ; Galactosylated ; Bovine serum albumin ; Nanoparticles ; Liver targeting
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2013-05-01
DOI: 10.1016/j.ijpharm.2013.03.019
卷: 448, 期:1, 页:79-86
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PROTEIN NANOPARTICLES ; CELLS ; OPTIMIZATION ; SUGARS
英文摘要:

In this study, galactosylated bovine serum albumin (GB), which could be developed for a liver targeting carrier was synthetized and it was identified by Fourier transform infrared (FT-IR) spectrometer. Oridonin loaded bovine serum albumin nanoparticle (ORI-BSA-NP) and oridonin loaded GB nanoparticle (ORI-GB-NP) were prepared and optimized by the desolvation technique. During the preparation of ORI-GB-NP, galactosamine was introduced to end-cap the free aldehyde groups on nanoparticles. The characteristics of ORI-GB-NP such as particle size, zeta potential, particle morphologie, entrapment efficiency and drug loading were evaluated. The nearly spherical nanoparticles, with a narrow size distribution below 200 nm, were negatively charged with zeta potential of about -30 mV. Meanwhile, differential scanning calorimetry (DSC) and X-ray diffraction confirmed the amorphous state of ORI in ORI-GB-NP. The in vitro drug release of ORI from ORI-GB-NP presented a biphasic pattern with an initial burst effect and consequently sustained release. These results implied that the nanoparticles possessed fine physicochemical characteristics and seemed to be a stable delivery system for poorly soluble oridonin. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000319052000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53828
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Jinan 250100, Shandong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Li, Caiyun,Zhang, Dianrui,Guo, Hejian,et al. Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,448(1):79-86.
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