学科主题 | 药学 |
Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin | |
Li, Caiyun1; Zhang, Dianrui1; Guo, Hejian1; Hao, Leilei1; Zheng, Dandan1; Liu, Guangpu1; Shen, Jingyi1; Tian, Xiaona1; Zhang, Qiang2 | |
关键词 | Oridonin Galactosylated Bovine Serum Albumin Nanoparticles Liver Targeting |
刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
![]() |
2013-05-01 | |
DOI | 10.1016/j.ijpharm.2013.03.019 |
卷 | 448期:1页:79-86 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Pharmacology & Pharmacy |
资助者 | National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) |
研究领域[WOS] | Pharmacology & Pharmacy |
关键词[WOS] | PROTEIN NANOPARTICLES ; CELLS ; OPTIMIZATION ; SUGARS |
英文摘要 | In this study, galactosylated bovine serum albumin (GB), which could be developed for a liver targeting carrier was synthetized and it was identified by Fourier transform infrared (FT-IR) spectrometer. Oridonin loaded bovine serum albumin nanoparticle (ORI-BSA-NP) and oridonin loaded GB nanoparticle (ORI-GB-NP) were prepared and optimized by the desolvation technique. During the preparation of ORI-GB-NP, galactosamine was introduced to end-cap the free aldehyde groups on nanoparticles. The characteristics of ORI-GB-NP such as particle size, zeta potential, particle morphologie, entrapment efficiency and drug loading were evaluated. The nearly spherical nanoparticles, with a narrow size distribution below 200 nm, were negatively charged with zeta potential of about -30 mV. Meanwhile, differential scanning calorimetry (DSC) and X-ray diffraction confirmed the amorphous state of ORI in ORI-GB-NP. The in vitro drug release of ORI from ORI-GB-NP presented a biphasic pattern with an initial burst effect and consequently sustained release. These results implied that the nanoparticles possessed fine physicochemical characteristics and seemed to be a stable delivery system for poorly soluble oridonin. (C) 2013 Elsevier B.V. All rights reserved. |
语种 | 英语 |
所属项目编号 | 2009CB930300 |
资助者 | National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) |
WOS记录号 | WOS:000319052000009 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/53828 |
Collection | 北京大学药学院 |
作者单位 | 1.Shandong Univ, Coll Pharm, Jinan 250100, Shandong, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China |
Recommended Citation GB/T 7714 | Li, Caiyun,Zhang, Dianrui,Guo, Hejian,et al. Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,448(1):79-86. |
APA | Li, Caiyun.,Zhang, Dianrui.,Guo, Hejian.,Hao, Leilei.,Zheng, Dandan.,...&Zhang, Qiang.(2013).Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin.INTERNATIONAL JOURNAL OF PHARMACEUTICS,448(1),79-86. |
MLA | Li, Caiyun,et al."Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin".INTERNATIONAL JOURNAL OF PHARMACEUTICS 448.1(2013):79-86. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment