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学科主题: 药学
题名:
Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water
作者: Lei, Meng1; Shi, Lanxiang1; Li, Gong1; Chen, Shilv3; Fang, Weihai3; Ge, Zemei1; Cheng, Tieming1; Li, Runtao1,2
关键词: organocatalysis ; asymmetric aldol reaction ; dipeptide ; in the presence of water
刊名: TETRAHEDRON
发表日期: 2007-08-13
DOI: 10.1016/j.tet.2007.05.077
卷: 63, 期:33, 页:7892-7898
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: AQUEOUS-MEDIA ; SMALL PEPTIDES ; ORGANIC-MOLECULES ; HIGHLY EFFICIENT ; PROLINE ; ORGANOCATALYST ; ALDEHYDES ; HYDROXYACETONE ; CHEMISTRY ; ADDITIONS
英文摘要:

The L-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 degrees C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee). (C) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000252082800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53829
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

Recommended Citation:
Lei, Meng,Shi, Lanxiang,Li, Gong,et al. Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water[J]. TETRAHEDRON,2007,63(33):7892-7898.
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