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Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water
Lei, Meng1; Shi, Lanxiang1; Li, Gong1; Chen, Shilv3; Fang, Weihai3; Ge, Zemei1; Cheng, Tieming1; Li, Runtao1,2
关键词Organocatalysis Asymmetric Aldol Reaction Dipeptide In The Presence Of Water
刊名TETRAHEDRON
2007-08-13
DOI10.1016/j.tet.2007.05.077
63期:33页:7892-7898
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]AQUEOUS-MEDIA ; SMALL PEPTIDES ; ORGANIC-MOLECULES ; HIGHLY EFFICIENT ; PROLINE ; ORGANOCATALYST ; ALDEHYDES ; HYDROXYACETONE ; CHEMISTRY ; ADDITIONS
英文摘要

The L-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 degrees C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee). (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000252082800014
引用统计
被引频次:85[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53829
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714
Lei, Meng,Shi, Lanxiang,Li, Gong,et al. Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water[J]. TETRAHEDRON,2007,63(33):7892-7898.
APA Lei, Meng.,Shi, Lanxiang.,Li, Gong.,Chen, Shilv.,Fang, Weihai.,...&Li, Runtao.(2007).Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water.TETRAHEDRON,63(33),7892-7898.
MLA Lei, Meng,et al."Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water".TETRAHEDRON 63.33(2007):7892-7898.
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