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Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors
Chen, Yao; Huang, Xiao-Jun; Wang, Yu; Liu, Kai-Yan; Chen, Huan; Chen, Yu-Hong; Zhang, Xiao-Hui; Wang, Feng-Rong; Han, Wei; Wang, Jing-Zhi; Yan, Chen-Hua; Zhang, Yuan-Yuan; Sun, Yu-Qian; Xu, Lan-Ping
刊名TRANSFUSION
2015-08-01
DOI10.1111/trf.13167
55期:8页:2023-2031
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]COLONY-STIMULATING FACTOR ; ADEQUATE PBSC COLLECTION ; MULTIPLE-MYELOMA ; G-CSF ; MOBILIZATION ; PLERIXAFOR ; CHEMOTHERAPY ; TRANSPLANTATION ; LYMPHOMA ; THERAPY
英文摘要

BACKGROUND: We reported febrile reaction after the infusion of haploidentical peripheral blood stem cells (PBSCs). The aim of this study was to better characterize this new clinical entity named by infusion-related febrile reaction (IRFR).

STUDY DESIGN AND METHODS: A retrospective analysis of 490 patients received allogeneic stem cell transplantation (SCT) between October 2009 and December 2011 at our institution.

RESULTS: The distribution of transplant type was 173 patients in HLA-identical siblings, 30 in unrelated, and 287 in haploidentical. IRFR was defined as unexplained fever of more than 38 degrees C within 24 hours after the infusion of allogeneic PBSCs. We did not observe any IRFRs in patients undergoing HLA-identical sibling and unrelated transfusions. After excluding patients with a known source of infection, we classified haploidentical patients into IRFR and non-IRFR groups. Eighty-eight patients (30.7%) of 287 cases after the infusion of haploidentical PBSCs were diagnosed as IRFRs, chills in 3.5% (10/88), diarrhea in 21.6% (19/88), an erythematous skin rash in 0.3% (1/88), hypoxemia in 1.0% (3/88), and no other accompanying symptoms in 62.5% (55/88). Significantly higher elevation of C-reactive protein and complement C3 was seen in the IRFR group compared with the non-IRFR group. Multivariate analysis showed higher CD34+ dose was a significant predictor for IRFR (p = 0.023; hazard ratio = 1.848; 95% confidence interval, 1.087-3.142).

CONCLUSION: As a clinical feature belonging to haploidentical SCT, IRFR was associated with the higher numbers of CD34+ from PBSCs.

语种英语
WOS记录号WOS:000359673300062
项目编号Z121107002612035
资助机构Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53835
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yao,Huang, Xiao-Jun,Wang, Yu,et al. Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors[J]. TRANSFUSION,2015,55(8):2023-2031.
APA Chen, Yao.,Huang, Xiao-Jun.,Wang, Yu.,Liu, Kai-Yan.,Chen, Huan.,...&Xu, Lan-Ping.(2015).Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors.TRANSFUSION,55(8),2023-2031.
MLA Chen, Yao,et al."Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors".TRANSFUSION 55.8(2015):2023-2031.
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