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学科主题: 药学
题名:
Metabolism of the Lignan Dehydrodiisoeugenol in Rats
作者: Li, Fei; Yang, Xiu-Wei
关键词: Myristicaceae ; Myristica fragrans ; lignans ; dehydrodiisoeugenol ; metabolism
刊名: PLANTA MEDICA
发表日期: 2011-10-01
DOI: 10.1055/s-0030-1271063
卷: 77, 期:15, 页:1712-1717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: MYRISTICA-FRAGRANS ; IN-VITRO ; MAMMALIAN LIGNANS ; LIVER MICROSOMES ; PLANT LIGNANS ; NEOLIGNANS ; BIOTRANSFORMATION ; MACE ; TRANSFORMATION ; COMPONENTS
英文摘要:

Dehydrodiisoeugenol (DDIE), a major active lignan from the seed and aril of the fruit of Myristica fragrans Houtt., functions as a potential anti-inflammatory agent by inhibiting lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. However, the metabolism of DDIE remains unknown. This report describes the metabolic fate of DDIE in liver microsomes, urine, and feces of rats treated with DDIE. DDIE metabolites were isolated by sequential column chromatography and high-performance liquid chromatography from liver microsomes incubations, urine, and feces. Nine metabolites (M-1 to M-9), including 5 new metabolites, were determined spectroscopically using ultra-violet (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and circular dichroism (CD). Analysis of the isolated metabolites showed that DDIE undergoes four major pathways of metabolism in the rat: oxidation (including hydroxylation, hydroformylation, and acetylation), demethylation, ring-opening, and dehydrogenation. In contrast to the metabolites from liver microsomes, the major metabolites in vivo were generated from DDIE by multiple metabolic reactions. Given these results, we describe a metabolic pathway for DDIE in the rat that gives insight into the metabolism of DDIE and the mechanism of DDIE bioactivity in humans.

语种: 英语
所属项目编号: 30973863 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A 01-02 ; Z0004105040311
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Beijing Municipal Special-Purpose Science Foundation of China
WOS记录号: WOS:000296188000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53837
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Li, Fei,Yang, Xiu-Wei. Metabolism of the Lignan Dehydrodiisoeugenol in Rats[J]. PLANTA MEDICA,2011,77(15):1712-1717.
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