IR@PKUHSC  > 北京大学药学院  > 天然药物学系
学科主题药学
Metabolism of the Lignan Dehydrodiisoeugenol in Rats
Li, Fei; Yang, Xiu-Wei
关键词Myristicaceae Myristica Fragrans Lignans Dehydrodiisoeugenol Metabolism
刊名PLANTA MEDICA
2011-10-01
DOI10.1055/s-0030-1271063
77期:15页:1712-1717
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]MYRISTICA-FRAGRANS ; IN-VITRO ; MAMMALIAN LIGNANS ; LIVER MICROSOMES ; PLANT LIGNANS ; NEOLIGNANS ; BIOTRANSFORMATION ; MACE ; TRANSFORMATION ; COMPONENTS
英文摘要

Dehydrodiisoeugenol (DDIE), a major active lignan from the seed and aril of the fruit of Myristica fragrans Houtt., functions as a potential anti-inflammatory agent by inhibiting lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. However, the metabolism of DDIE remains unknown. This report describes the metabolic fate of DDIE in liver microsomes, urine, and feces of rats treated with DDIE. DDIE metabolites were isolated by sequential column chromatography and high-performance liquid chromatography from liver microsomes incubations, urine, and feces. Nine metabolites (M-1 to M-9), including 5 new metabolites, were determined spectroscopically using ultra-violet (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and circular dichroism (CD). Analysis of the isolated metabolites showed that DDIE undergoes four major pathways of metabolism in the rat: oxidation (including hydroxylation, hydroformylation, and acetylation), demethylation, ring-opening, and dehydrogenation. In contrast to the metabolites from liver microsomes, the major metabolites in vivo were generated from DDIE by multiple metabolic reactions. Given these results, we describe a metabolic pathway for DDIE in the rat that gives insight into the metabolism of DDIE and the mechanism of DDIE bioactivity in humans.

语种英语
WOS记录号WOS:000296188000008
项目编号30973863 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A 01-02 ; Z0004105040311
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Beijing Municipal Special-Purpose Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53837
专题北京大学药学院_天然药物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Fei,Yang, Xiu-Wei. Metabolism of the Lignan Dehydrodiisoeugenol in Rats[J]. PLANTA MEDICA,2011,77(15):1712-1717.
APA Li, Fei,&Yang, Xiu-Wei.(2011).Metabolism of the Lignan Dehydrodiisoeugenol in Rats.PLANTA MEDICA,77(15),1712-1717.
MLA Li, Fei,et al."Metabolism of the Lignan Dehydrodiisoeugenol in Rats".PLANTA MEDICA 77.15(2011):1712-1717.
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