IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice
Qui, B; Mei, QB; Ma, JJ; Korsten, MA
关键词Nitric Oxide Pancreatitis Cerulein Myeloperoxidase Mice
刊名PANCREAS
2001-07-01
23期:1页:89-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; L-ARGININE ; MICROCIRCULATORY DISTURBANCES ; INTESTINAL INFLAMMATION ; LEUKOCYTE ADHESION ; BLOOD-FLOW ; RAT MODEL ; INTERLEUKIN-6 ; SECRETION ; INHIBITION
英文摘要

Production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been proposed as a pathogenic factor in acute pancreatitis, but its role has still not been fully examined. The present study explored the role of iNOS in cerulein-induced acute pancreatitis using iNOS-deficient mice. Twelve- to 14-weck-old male mice (C57B1/6 and iNOS-deficient) were administered cerulein by intraperitoneal (i.p.) injection at hourly intervals for 7 hours and killed 24 hours later after the first dose. Pancreatic wet weight, pancreatic myeloperoxidase (MPO) activity, and levels of plasma nitrite and serum amylase were measured. In another experiment isosorbide: dinitrate tan NO donor) was given by oral gavage every 6 hours for 24 hours beginning simultaneously with cerulein injections in iNOS-deficient mice. Cerulein administration dose-dependently increased pancreatic wet weight, myeloperoxidase activity, and levels of nitrite and amylase in C57B1/6 mice. These parameters (except nitrite levels) were significantly intensified in iNOS-deficient mice. At the dose employed, cerulein failed to increase nitrite levels in iNOS-deficient mice. The susceptibility to cerulein toxicity in iNOS-deficient mice was abolished by NO donor treatment. NO release from an iNOS source appears to play a protective role in cerulein-induced pancreatitis. At least in part, NO may prevent neutrophil accumulation after cerulein administration.

语种英语
WOS记录号WOS:000169543500013
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53839
Collection北京大学基础医学院_药理学系
作者单位1.Vet Adm Med Ctr, Med Program 111, Bronx, NY 10468 USA
2.Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
3.CUNY Mt Sinai Sch Med, New York, NY 10029 USA
4.Beijing Med Univ, Dept Pharmacol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Qui, B,Mei, QB,Ma, JJ,et al. Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice[J]. PANCREAS,2001,23(1):89-93.
APA Qui, B,Mei, QB,Ma, JJ,&Korsten, MA.(2001).Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice.PANCREAS,23(1),89-93.
MLA Qui, B,et al."Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice".PANCREAS 23.1(2001):89-93.
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