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学科主题基础医学
In Vivo Study of Ligament-Bone Healing after Anterior Cruciate Ligament Reconstruction Using Autologous Tendons with Mesenchymal Stem Cells Affinity Peptide Conjugated Electrospun Nanofibrous Scaffold
Zhu, Jingxian1,2; Zhang, Xin2; Shao, Zhenxing2; Dai, Linghui1; Li, La2; Hu, Xiaoqing2; Wang, Xiaokun3; Zhou, Chunyan1; Ao, Yingfang2
刊名JOURNAL OF NANOMATERIALS
2013
DOI10.1155/2013/831873
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]DIFFERENTIATION ; MSC ; PHOSPHATE ; MESHES ; MODEL
英文摘要

Electrospinning nanofibrous scaffold was commonly used in tissue regeneration recently. Nanofibers with specific topological characteristics were reported to be able to induce osteogenic differentiation of MSCs. In this in vivo study, autologous tendon grafts with lattice-like nanofibrous scaffold wrapping at two ends of autologous tendon were used to promote early stage of ligament-bone healing after rabbit ACL reconstruction. To utilize native MSCs from bone marrow, an MSCs specific affinity peptide E7 was conjugated to nanofibrous meshes. After 3 months, H-E assessment and specific staining of collagen type I, II, and III showed direct ligament-bone insertion with typical four zones (bone, calcified fibrocartilage, fibrocartilage, and ligament) in bioactive scaffold reconstruction group. Diameters of bone tunnel were smaller in nanofibrous scaffold conjugated E7 peptide group than those in control group. The failure load of substitution complex also indicated a stronger ligament-bone insertion healing using bioactive scaffold. In conclusion, lattice-like nanofibrous scaffold with specific MSCs affinity peptide has great potential in promoting early stage of ligament-bone healing after ACL reconstruction.

语种英语
WOS记录号WOS:000327310600001
项目编号81171726 ; 81101390 ; 2012CB933903
资助机构National Natural Science Foundation of China ; National Basic Research Program of China ; China Postdoctoral Science Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53840
专题北京大学第三临床医学院_运动医学研究所
北京大学基础医学院
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
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GB/T 7714
Zhu, Jingxian,Zhang, Xin,Shao, Zhenxing,et al. In Vivo Study of Ligament-Bone Healing after Anterior Cruciate Ligament Reconstruction Using Autologous Tendons with Mesenchymal Stem Cells Affinity Peptide Conjugated Electrospun Nanofibrous Scaffold[J]. JOURNAL OF NANOMATERIALS,2013.
APA Zhu, Jingxian.,Zhang, Xin.,Shao, Zhenxing.,Dai, Linghui.,Li, La.,...&Ao, Yingfang.(2013).In Vivo Study of Ligament-Bone Healing after Anterior Cruciate Ligament Reconstruction Using Autologous Tendons with Mesenchymal Stem Cells Affinity Peptide Conjugated Electrospun Nanofibrous Scaffold.JOURNAL OF NANOMATERIALS.
MLA Zhu, Jingxian,et al."In Vivo Study of Ligament-Bone Healing after Anterior Cruciate Ligament Reconstruction Using Autologous Tendons with Mesenchymal Stem Cells Affinity Peptide Conjugated Electrospun Nanofibrous Scaffold".JOURNAL OF NANOMATERIALS (2013).
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