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学科主题: 临床医学
题名:
EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES
作者: Tang, X.1; Fan, L.1; Pei, M.2; Zeng, L.3; Ge, Z.1,4
关键词: Chondrogenic differentiation ; chondrogenesis ; mesenchymal stem cells ; chondrocytes ; chondrogenic differentiation factors
刊名: EUROPEAN CELLS & MATERIALS
发表日期: 2015-07-01
卷: 30, 页:12-27
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Cell Biology ; Engineering ; Materials Science
关键词[WOS]: MESENCHYMAL STEM-CELLS ; IN-VITRO CHONDROGENESIS ; GROWTH-FACTOR-BETA ; ARTICULAR-CARTILAGE FORMATION ; LIMB-BUD CHONDROGENESIS ; HORMONE-RELATED PROTEIN ; MARROW STROMAL CELLS ; BONE-MARROW ; TGF-BETA ; PROGENITOR CELLS
英文摘要:

As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.

语种: 英语
所属项目编号: 2012CB619100 ; 81271722 ; 81471800
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000366141600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53848
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
2.W Virginia Univ, Dept Orthopaed, Stem Cell & Tissue Engn Lab, Morgantown, WV 26506 USA
3.Tufts Univ, Sch Med, Dept Integrat Physiol & Pathobiol, Boston, MA 02111 USA
4.Peking Univ, Peoples Hosp, Arthrits Clin & Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Tang, X.,Fan, L.,Pei, M.,et al. EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES[J]. EUROPEAN CELLS & MATERIALS,2015,30:12-27.
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