IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES
Tang, X.1; Fan, L.1; Pei, M.2; Zeng, L.3; Ge, Z.1,4
关键词Chondrogenic Differentiation Chondrogenesis Mesenchymal Stem Cells Chondrocytes Chondrogenic Differentiation Factors
刊名EUROPEAN CELLS & MATERIALS
2015-07-01
30页:12-27
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Cell Biology ; Engineering ; Materials Science
关键词[WOS]MESENCHYMAL STEM-CELLS ; IN-VITRO CHONDROGENESIS ; GROWTH-FACTOR-BETA ; ARTICULAR-CARTILAGE FORMATION ; LIMB-BUD CHONDROGENESIS ; HORMONE-RELATED PROTEIN ; MARROW STROMAL CELLS ; BONE-MARROW ; TGF-BETA ; PROGENITOR CELLS
英文摘要

As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.

语种英语
WOS记录号WOS:000366141600002
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53848
专题北京大学第二临床医学院
北京大学第三临床医学院_呼吸科
作者单位1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
2.W Virginia Univ, Dept Orthopaed, Stem Cell & Tissue Engn Lab, Morgantown, WV 26506 USA
3.Tufts Univ, Sch Med, Dept Integrat Physiol & Pathobiol, Boston, MA 02111 USA
4.Peking Univ, Peoples Hosp, Arthrits Clin & Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Tang, X.,Fan, L.,Pei, M.,et al. EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES[J]. EUROPEAN CELLS & MATERIALS,2015,30:12-27.
APA Tang, X.,Fan, L.,Pei, M.,Zeng, L.,&Ge, Z..(2015).EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES.EUROPEAN CELLS & MATERIALS,30,12-27.
MLA Tang, X.,et al."EVOLVING CONCEPTS OF CHONDROGENIC DIFFERENTIATION: HISTORY, STATE-OF-THE-ART AND FUTURE PERSPECTIVES".EUROPEAN CELLS & MATERIALS 30(2015):12-27.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tang, X.]的文章
[Fan, L.]的文章
[Pei, M.]的文章
百度学术
百度学术中相似的文章
[Tang, X.]的文章
[Fan, L.]的文章
[Pei, M.]的文章
必应学术
必应学术中相似的文章
[Tang, X.]的文章
[Fan, L.]的文章
[Pei, M.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。