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学科主题口腔医学
Fibroblasts Regulate Variable Aggressiveness of Syndromic Keratocystic and Non-syndromic Odontogenic Tumors
Hong, Y. -Y.1; Yu, F. -Y.1; Qu, J. -F.1; Chen, F.2; Li, T. -J.1
关键词Ptch1 Nevoid Basal Cell Carcinoma Syndrome Keratocystic Odontogenic Tumors Osteogenesis Osteoclastogenesis Stroma Cell
刊名JOURNAL OF DENTAL RESEARCH
2014-09-01
DOI10.1177/0022034514542108
93期:9页:904-910
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CELL CARCINOMA SYNDROME ; GORLIN SYNDROME ; STEM-CELLS ; CANCER ; MICROENVIRONMENT ; EXPRESSION ; MUTATIONS ; INVASION ; FEATURES ; RANKL
英文摘要

Keratocystic odontogenic tumors (KCOTs) are jaw lesions that can be either sporadic or associated with nevoid basal cell carcinoma syndrome, which typically occurs as multiple, aggressive lesions that can lead to large areas of bone destruction and resorption and cause major impairment and even jaw fracture. To clarify the role of fibroblasts in the aggressivness of syndromic (S-) as compared with non-syndromic (NS-) KCOTs, we assessed fibroblasts derived from 16 S- and NS-KCOTs for differences in cell proliferation, multilineage differentiation potential, alkaline phosphatase activity, and osteoclastogenic potential. S-KCOT fibroblasts had proliferative and osteoclastogenic capacity higher than those from NS-KCOTs, as evidenced by higher numbers of tartrate-resistant acid-phosphatase-positive multinuclear cells, expression of cyclooxygenase 2, and ratio of receptor activator of nuclear factor-kappa B ligand to osteoprotegerin. The osteogenic potential was higher for S- than for NS-KCOT fibroblasts and was associated with lower mRNA expression of runt-related transcription factor 2, collagen type I 1, osteocalcin, and osteopontin as well as reduced alkaline phosphatase activity. These results suggest that the distinct characteristics of fibroblasts in KCOTs are responsible for the greater aggressiveness observed in the syndromic subtype.Abbreviations: AP, alkaline phosphatase; CK, cytokeratin; COL1A1, collagen type I 1; COX-2, cyclooxygenase-2; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-1, interleukin 1; KCOT, keratocystic odontogenic tumor; NBCCS, nevoid basal cell carcinoma syndrome; NS-KCOT, non-syndrome-associated KCOT; OCN, osteocalcin; OPG, osteoprotegerin; OPN, osteopontin; RANKL, receptor activator of nuclear factor-kappa B ligand; Runx2, runt-related transcription factor 2; S-KCOT, syndrome-associated KCOT; TAF, tumor-associated fibroblast; and TRAP, tartrate-resistant acid phosphatase.

语种英语
所属项目编号81030018 ; 30872900
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000342770400011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53851
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Hong, Y. -Y.,Yu, F. -Y.,Qu, J. -F.,et al. Fibroblasts Regulate Variable Aggressiveness of Syndromic Keratocystic and Non-syndromic Odontogenic Tumors[J]. JOURNAL OF DENTAL RESEARCH,2014,93(9):904-910.
APA Hong, Y. -Y.,Yu, F. -Y.,Qu, J. -F.,Chen, F.,&Li, T. -J..(2014).Fibroblasts Regulate Variable Aggressiveness of Syndromic Keratocystic and Non-syndromic Odontogenic Tumors.JOURNAL OF DENTAL RESEARCH,93(9),904-910.
MLA Hong, Y. -Y.,et al."Fibroblasts Regulate Variable Aggressiveness of Syndromic Keratocystic and Non-syndromic Odontogenic Tumors".JOURNAL OF DENTAL RESEARCH 93.9(2014):904-910.
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