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IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories
作者: Xue, Yan-Xue3; Xue, Li-Fen1,2,3,4; Liu, Jian-Feng1,2,3; He, Jia1,2,3; Deng, Jia-Hui1,2,3; Sun, Shi-Chao1,2,3; Han, Hai-Bin5; Luo, Yi-Xiao1,2,3; Xu, Ling-Zhi1,2,3; Wu, Ping3; Lu, Lin1,2,3,6,7
关键词: addiction ; amygdala ; extinction ; memory ; perineuronal nets
刊名: JOURNAL OF NEUROSCIENCE
发表日期: 2014-05-07
DOI: 10.1523/JNEUROSCI.5390-13.2014
卷: 34, 期:19, 页:6647-6658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NUCLEUS-ACCUMBENS CORE ; PARVALBUMIN-CONTAINING NEURONS ; COCAINE-SEEKING BEHAVIOR ; CENTRAL-NERVOUS-SYSTEM ; EXTRACELLULAR-MATRIX ; CHONDROITINASE ABC ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; INDUCED REINSTATEMENT ; RELAPSE PREVENTION
英文摘要:

Extinction therapy has been suggested to suppress the conditioned motivational effect of drug cues to prevent relapse. However, extinction forms a new inhibiting memory rather than erasing the original memory trace and drug memories invariably return. Perineuronal nets (PNNs) are a specialized extracellular matrix around interneurons in the brain that have been suggested to be a permissive factor that allows synaptic plasticity in the adolescent brain. The degradation of PNNs caused by chondroitinase ABC (ChABC) may generate induced juvenile-like plasticity (iPlasticity) and promote experience-dependent plasticity in the adult brain. In the present study, we investigated the effect of removing PNNs in the amygdala of rat on the extinction of drug memories. We found that extinction combined with intra-amygdala injections of ChABC (0.01 U/side) prevented the subsequent priming-induced reinstatement of morphine-induced and cocaine-induced, but not food-induced, conditioned place preference (CPP). Intra-amygdala injections of ChABC alone had no effect on the retention, retrieval, or relearning of morphine-induced CPP and storage of acquired food-induced CPP. Moreover, we found that the procedure facilitated the extinction of heroin-and cocaine-seeking behavior and prevented the spontaneous recovery and drug-induced reinstatement of heroin-and cocaine-seeking behavior. We also found that the effect of PNNs degradation combined with extinction may be mediated by the potentiation of several plasticity-related proteins in the amygdala. Altogether, our findings demonstrate that a combination of extinction training with PNNs degradation in the amygdala erases drug memories and suggest that ChABC may be an attractive candidate for the prevention of relapse.

语种: 英语
所属项目编号: 81271489 ; 31230033 ; 31300930 ; 91132716 ; 20130001120135
项目资助者: Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000336380500023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53854
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China
5.Ctr Tianjin Mental Hlth, Tianjin 300222, Peoples R China
6.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
7.Peking Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Xue, Yan-Xue,Xue, Li-Fen,Liu, Jian-Feng,et al. Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories[J]. JOURNAL OF NEUROSCIENCE,2014,34(19):6647-6658.
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