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Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories
Xue, Yan-Xue3; Xue, Li-Fen1,2,3,4; Liu, Jian-Feng1,2,3; He, Jia1,2,3; Deng, Jia-Hui1,2,3; Sun, Shi-Chao1,2,3; Han, Hai-Bin5; Luo, Yi-Xiao1,2,3; Xu, Ling-Zhi1,2,3; Wu, Ping3; Lu, Lin1,2,3,6,7
关键词Addiction Amygdala Extinction Memory Perineuronal Nets
刊名JOURNAL OF NEUROSCIENCE
2014-05-07
DOI10.1523/JNEUROSCI.5390-13.2014
34期:19页:6647-6658
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NUCLEUS-ACCUMBENS CORE ; PARVALBUMIN-CONTAINING NEURONS ; COCAINE-SEEKING BEHAVIOR ; CENTRAL-NERVOUS-SYSTEM ; EXTRACELLULAR-MATRIX ; CHONDROITINASE ABC ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; INDUCED REINSTATEMENT ; RELAPSE PREVENTION
英文摘要

Extinction therapy has been suggested to suppress the conditioned motivational effect of drug cues to prevent relapse. However, extinction forms a new inhibiting memory rather than erasing the original memory trace and drug memories invariably return. Perineuronal nets (PNNs) are a specialized extracellular matrix around interneurons in the brain that have been suggested to be a permissive factor that allows synaptic plasticity in the adolescent brain. The degradation of PNNs caused by chondroitinase ABC (ChABC) may generate induced juvenile-like plasticity (iPlasticity) and promote experience-dependent plasticity in the adult brain. In the present study, we investigated the effect of removing PNNs in the amygdala of rat on the extinction of drug memories. We found that extinction combined with intra-amygdala injections of ChABC (0.01 U/side) prevented the subsequent priming-induced reinstatement of morphine-induced and cocaine-induced, but not food-induced, conditioned place preference (CPP). Intra-amygdala injections of ChABC alone had no effect on the retention, retrieval, or relearning of morphine-induced CPP and storage of acquired food-induced CPP. Moreover, we found that the procedure facilitated the extinction of heroin-and cocaine-seeking behavior and prevented the spontaneous recovery and drug-induced reinstatement of heroin-and cocaine-seeking behavior. We also found that the effect of PNNs degradation combined with extinction may be mediated by the potentiation of several plasticity-related proteins in the amygdala. Altogether, our findings demonstrate that a combination of extinction training with PNNs degradation in the amygdala erases drug memories and suggest that ChABC may be an attractive candidate for the prevention of relapse.

语种英语
WOS记录号WOS:000336380500023
项目编号81271489 ; 31230033 ; 31300930 ; 91132716 ; 20130001120135
资助机构Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53854
专题北京大学精神卫生研究所
北京大学医学部管理机构_医学部
中国药物依赖性研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China
5.Ctr Tianjin Mental Hlth, Tianjin 300222, Peoples R China
6.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
7.Peking Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xue, Yan-Xue,Xue, Li-Fen,Liu, Jian-Feng,et al. Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories[J]. JOURNAL OF NEUROSCIENCE,2014,34(19):6647-6658.
APA Xue, Yan-Xue.,Xue, Li-Fen.,Liu, Jian-Feng.,He, Jia.,Deng, Jia-Hui.,...&Lu, Lin.(2014).Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories.JOURNAL OF NEUROSCIENCE,34(19),6647-6658.
MLA Xue, Yan-Xue,et al."Depletion of Perineuronal Nets in the Amygdala to Enhance the Erasure of Drug Memories".JOURNAL OF NEUROSCIENCE 34.19(2014):6647-6658.
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