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学科主题: 临床医学
题名:
BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation
作者: Yu, Bo2,3; Shao, Yong2,3; Zhang, Chao3; Chen, Yuewen1; Zhong, Qili2; Zhang, Jie2; Yang, Hong2,3; Zhang, Wei1; Wan, Jun3,4
关键词: BS69 ; SUMO ; Neuronal differentiation ; Muscle differentiation
刊名: EXPERIMENTAL CELL RESEARCH
发表日期: 2009-12-10
DOI: 10.1016/j.yexcr.2009.09.011
卷: 315, 期:20, 页:3543-3553
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: ADENOVIRUS E1A-ASSOCIATED PROTEIN ; NUCLEAR-BODIES ; PIAS PROTEINS ; TRANSCRIPTION FACTORS ; GENE-EXPRESSION ; P53 ACTIVITY ; C-JUN ; REGULATOR ; LIGASES ; FAMILY
英文摘要:

BS69, an adenovirus E1A binding protein, has been described as a co-repressor in association with various transcription factors. But its characteristics and exact biological functions remain largely unknown at present. Now we intensively investigated the localization of BS69 and its various truncated derivatives and found that: (a) BS69 forms oligomer through its C-terminus and (b) both PHD and MYND domain are important for the localization of BS69. Furthermore, we provided evidence showing that BS69 interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and Ubc9 (the only SUMO E2 enzyme so far identified) through its distinct regions. And PIAS1 significantly increases the SUMO modification of BS69. More importantly, in terms of the biological function of BS69, we found that BS69 plays an inhibitory role in the muscle and neuronal differentiation process. By taking advantage of several PHD and MYND domain mutants of BS69, we found that the PHD domain plays indispensable roles in the localization, sumoylation and function of BS69. Thus, our work contributed to the more intensive understanding of BS69. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000272426100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53856
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangzhou, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Yu, Bo,Shao, Yong,Zhang, Chao,et al. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation[J]. EXPERIMENTAL CELL RESEARCH,2009,315(20):3543-3553.
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