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学科主题临床医学
BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation
Yu, Bo2,3; Shao, Yong2,3; Zhang, Chao3; Chen, Yuewen1; Zhong, Qili2; Zhang, Jie2; Yang, Hong2,3; Zhang, Wei1; Wan, Jun3,4
关键词Bs69 Sumo Neuronal Differentiation Muscle Differentiation
刊名EXPERIMENTAL CELL RESEARCH
2009-12-10
DOI10.1016/j.yexcr.2009.09.011
315期:20页:3543-3553
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]ADENOVIRUS E1A-ASSOCIATED PROTEIN ; NUCLEAR-BODIES ; PIAS PROTEINS ; TRANSCRIPTION FACTORS ; GENE-EXPRESSION ; P53 ACTIVITY ; C-JUN ; REGULATOR ; LIGASES ; FAMILY
英文摘要

BS69, an adenovirus E1A binding protein, has been described as a co-repressor in association with various transcription factors. But its characteristics and exact biological functions remain largely unknown at present. Now we intensively investigated the localization of BS69 and its various truncated derivatives and found that: (a) BS69 forms oligomer through its C-terminus and (b) both PHD and MYND domain are important for the localization of BS69. Furthermore, we provided evidence showing that BS69 interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and Ubc9 (the only SUMO E2 enzyme so far identified) through its distinct regions. And PIAS1 significantly increases the SUMO modification of BS69. More importantly, in terms of the biological function of BS69, we found that BS69 plays an inhibitory role in the muscle and neuronal differentiation process. By taking advantage of several PHD and MYND domain mutants of BS69, we found that the PHD domain plays indispensable roles in the localization, sumoylation and function of BS69. Thus, our work contributed to the more intensive understanding of BS69. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000272426100008
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53856
专题北京大学深圳医院
作者单位1.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangzhou, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
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Yu, Bo,Shao, Yong,Zhang, Chao,et al. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation[J]. EXPERIMENTAL CELL RESEARCH,2009,315(20):3543-3553.
APA Yu, Bo.,Shao, Yong.,Zhang, Chao.,Chen, Yuewen.,Zhong, Qili.,...&Wan, Jun.(2009).BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation.EXPERIMENTAL CELL RESEARCH,315(20),3543-3553.
MLA Yu, Bo,et al."BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation".EXPERIMENTAL CELL RESEARCH 315.20(2009):3543-3553.
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