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学科主题: 基础医学
题名:
Coinfection with HIV-1 Alleviates Iron Accumulation in Patients with Chronic Hepatitis C Virus Infection
作者: Liu, Yuan1,2,3; Lv, Quanjun3; Gao, Jian1,2; Long, Lu1,2; Duan, Zhaojun1,2; Liang, Hua4; Shen, Tao1,2; Lu, Fengmin1,2
刊名: PLOS ONE
发表日期: 2014-06-13
DOI: 10.1371/journal.pone.0098039
卷: 9, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHRONIC VIRAL-HEPATITIS ; HEPCIDIN ; THERAPY ; DISEASE ; FERROPORTIN ; METABOLISM ; MECHANISMS ; LIVER ; HCV
英文摘要:

Most chronically-infected hepatitis C virus (HCV) patients have increased levels of iron in the liver. Iron overload reduces sustained responses to antiviral therapy, leading to more rapid progression to liver cirrhosis and the development of hepatocellular carcinoma. However, it is still unclear how HIV-1 infection affects iron status in patients chronically infected with HCV. The present study recruited 227 patients from a village in central China. These patients were either monoinfected with HCV (n = 129) or coinfected with HCV/HIV-1 (n = 98). Healthy controls (n = 84) were also recruited from the same village. Indicators of iron status, such as serum levels of iron, ferritin, and transferrin, total iron-binding capacity (TIBC), transferrin saturation (Tfs), and hepcidin, were analyzed and compared across the three groups. The results showed that serum levels of iron (p = 0.001) and ferritin (p = 0.009) and the Tfs (p = 0.002) were significantly higher in HCV-monoinfected patients than in the healthy controls; however, there were no differences in iron levels and Tfs between HCV/HIV-1 coinfected patients and healthy controls. Additionally, although serum hepcidin levels in HCV-monoinfected and HCV/HIV-1-coinfected patients were lower (p<0.001) than those in health controls, the levels in coinfected patients were higher (p = 0.025) than those in HCV-monoinfected patients. Serum iron and ferritin levels in HCV-monoinfected patients were positively correlated with serum ALT/AST. Serum transferrin levels were negatively correlated with ALT/AST levels. The levels of iron in the serum of coinfected patients with a CD4+T-cell count <500/mu l were lower than those in patients with a CD4+T-cell count >= 500/mu l, whereas serum hepcidin levels showed the opposite trend. Taken together, these results suggest that coinfection with HIV-1 alleviates iron accumulation caused by chronic HCV infection. Our study indicated that determining the status of serum iron and other iron-associated parameters will be helpful to understand the complexity of alternations in iron distribution in HCV/HIV-1-coinfected patients.

语种: 英语
所属项目编号: 81271826 ; 7122108 ; 2012ZX10002003 ; 2012ZX10002005
项目资助者: National Natural Science of China ; National Science Foundation of Beijing ; National S& ; T Major Project for Infectious Diseases
WOS记录号: WOS:000338278100011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53858
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China
4.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China

Recommended Citation:
Liu, Yuan,Lv, Quanjun,Gao, Jian,et al. Coinfection with HIV-1 Alleviates Iron Accumulation in Patients with Chronic Hepatitis C Virus Infection[J]. PLOS ONE,2014,9(6).
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