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学科主题基础医学
Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development
Chen, XQ; Liu, S; Qin, LY; Wang, CR; Fung, YWW; Yu, ACH
关键词14-3-3 14-3-3 eta neuron astrocytes gene expression RT-PCR
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2005
DOI10.1002/jnr.20323
79期:1-2页:114-118
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; SIGNAL-TRANSDUCTION ; NERVOUS-SYSTEM ; TRK RECEPTORS ; CELL-DIVISION ; GROWTH-FACTOR ; PROTEIN ; EXPRESSION ; BRAIN ; 14-3-3-PROTEINS
英文摘要

The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and xi) in the brain remain unclear. We have reported previously upregulation of 14-3-3gamma in ischemic astrocytes. In the present study, we report selective regulation of 14-3-3eta in cultured cerebral cortical neurons and astrocytes during in vitro development. In cultured neurons, gene expression levels of 14-3-3eta increase with culture age (0-10 days). Brain-derived neurotrophic factor and neurotrophin-3 upregulate 14-3-3eta gene expression. In cultured astrocytes, 14-3-3eta is downregulated with culture age (1-5 weeks). The gene expression level of 14-3-3eta is not affected by scratch injury in astrocytes or by ischemia in neurons. These data suggest a possible role of 14-3-3eta in growth and differentiation of neurons and astrocytes, indicating an intricate mechanism governing coordinated and well-controlled developmental events in the brain to ensure normal neural functions. (C) 2004 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000226390800016
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53860
专题北京大学基础医学院_神经生物学系
作者单位1.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr,Dept Neurobiol, Minist Educ,Key Lab Neurosci, Beijing 100083, Peoples R China
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Chen, XQ,Liu, S,Qin, LY,et al. Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2005,79(1-2):114-118.
APA Chen, XQ,Liu, S,Qin, LY,Wang, CR,Fung, YWW,&Yu, ACH.(2005).Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development.JOURNAL OF NEUROSCIENCE RESEARCH,79(1-2),114-118.
MLA Chen, XQ,et al."Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development".JOURNAL OF NEUROSCIENCE RESEARCH 79.1-2(2005):114-118.
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