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学科主题: 基础医学
题名:
Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development
作者: Chen, XQ; Liu, S; Qin, LY; Wang, CR; Fung, YWW; Yu, ACH
关键词: 14-3-3 ; 14-3-3 eta ; neuron ; astrocytes ; gene expression ; RT-PCR
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2005
DOI: 10.1002/jnr.20323
卷: 79, 期:1-2, 页:114-118
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; SIGNAL-TRANSDUCTION ; NERVOUS-SYSTEM ; TRK RECEPTORS ; CELL-DIVISION ; GROWTH-FACTOR ; PROTEIN ; EXPRESSION ; BRAIN ; 14-3-3-PROTEINS
英文摘要:

The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and xi) in the brain remain unclear. We have reported previously upregulation of 14-3-3gamma in ischemic astrocytes. In the present study, we report selective regulation of 14-3-3eta in cultured cerebral cortical neurons and astrocytes during in vitro development. In cultured neurons, gene expression levels of 14-3-3eta increase with culture age (0-10 days). Brain-derived neurotrophic factor and neurotrophin-3 upregulate 14-3-3eta gene expression. In cultured astrocytes, 14-3-3eta is downregulated with culture age (1-5 weeks). The gene expression level of 14-3-3eta is not affected by scratch injury in astrocytes or by ischemia in neurons. These data suggest a possible role of 14-3-3eta in growth and differentiation of neurons and astrocytes, indicating an intricate mechanism governing coordinated and well-controlled developmental events in the brain to ensure normal neural functions. (C) 2004 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000226390800016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53860
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr,Dept Neurobiol, Minist Educ,Key Lab Neurosci, Beijing 100083, Peoples R China

Recommended Citation:
Chen, XQ,Liu, S,Qin, LY,et al. Selective regulation of 14-3-3 eta in primary culture of cerebral cortical neurons and astrocytes during development[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2005,79(1-2):114-118.
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