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学科主题: 临床医学
题名:
Prevalence and factors associated with CKD: A population study from Beijing
作者: Zhang, LuXia1,4; Zhang, PuHong2; Wang, Fang1,4; Zuo, Li1,4; Zhou, Ying2; Shi, Ying2; Li, Gang2; Jiao, ShuFang2; Liu, ZeJun2; Liang, WanNian3; Wang, HaiYan1,4
关键词: chronic kidney disease ; screening ; China ; albuminuria ; kidney function
刊名: AMERICAN JOURNAL OF KIDNEY DISEASES
发表日期: 2008-03-01
DOI: 10.1053/j.ajkd.2007.11.009
卷: 51, 期:3, 页:373-384
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; STAGE RENAL-DISEASE ; MICROSCOPIC HEMATURIA ; CLINICAL EPIDEMIOLOGY ; ANALGESIC NEPHROPATHY ; BLOOD-PRESSURE ; UNITED-STATES ; ADULTS ; RISK ; MEN
英文摘要:

Background: Chronic kidney disease (CKD) is considered a serious worldwide public health problem, but data from developing countries are extremely limited.

Study Design: Cross-sectional study.

Setting and Participants: A representative sample of 13,925 adults in Beijing, China.

Predictors: Age (18 to 39, 40 to 59, 60 to 69, and >70 years), sex, urban or rural area, history of chronic respiratory infection and cardiovascular disease, hepatitis B virus infection, smoking, family history (diabetes, hypertension, and CKID), nephrotoxic medications, central obesity, diabetic and hypertension status, and dyslipidemia.

Outcomes and Measurements: CKID was defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) or markers of kidney damage. Glomerular filtration rate was estimated by using calibrated serum creatinine level and a formula specific for China. Persistent albuminuria and hematuria were considered markers of kidney damage.

Results: The prevalence of CKID in adults in Beijing was 13.0% (95% confidence interval [CI], 11.9 to 14.2). It therefore was estimated that the number of adults in Beijing with CKID was 1.43 million. In subjects aged 18 to 39, 40 to 59, 60 to 69, and older than 70 years, prevalences of CKID were 10.0% (95% CI, 8.9 to 11.3),14.2% (95% CI, 13.0 to 15.4),20.8% (95% CI, 18.1 to 23.9), and 30.5% (95% CI, 26.6 to 34.7), respectively. Factors independently associated with decreased kidney function included older age (odds ratio [OR], 1.83; 95% CI, 1.51 to 2.22 per 10-year increase), nephrotoxic medications (OR, 2.19; 95% CI, 1.21 to 3.97), rural area (versus urban area; OR, 0.47; 95% CI, 0.28 to 0.78), history of cardiovascular disease (OR, 2.04; 95% CI, 1.24 to 3.38), high-density lipoprotein cholesterol level less than 40 mg/dL (OR, 3.00; 95% CI, 1.39 to 6.51), and hypertension status (with duration > 10 years; OR, 1.85; 95% CI, 1.19 to 2.88).

Limitations: Kidney function and indicators of kidney damage were based on single measurements.

Conclusions: CKD is a public health burden in Beijing.

语种: 英语
WOS记录号: WOS:000254799900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53861
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Beijing Municipal Hlth Bur, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China
3.Beijing Ctr Dis Control & Prevent, Inst Chron & Noncommunicable Dis Control & Preven, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, LuXia,Zhang, PuHong,Wang, Fang,et al. Prevalence and factors associated with CKD: A population study from Beijing[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2008,51(3):373-384.
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