北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
Biochemical pregnancy and spontaneous abortion in first IVF cycles are negative predictors for subsequent cycles: an over 10,000 cases cohort study
作者: Yang, Rui; Yang, Shuo; Li, Rong; Chen, Xinna; Wang, Haiyan; Ma, Caihong; Liu, Ping; Qiao, Jie
关键词: Biochemical pregnancy ; Spontaneous abortion ; Predictive value ; Clinical significance ; In vitro fertilization and embryo transfer
刊名: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
发表日期: 2015-08-01
DOI: 10.1007/s00404-015-3639-8
卷: 292, 期:2, 页:453-458
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: 研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: IN-VITRO FERTILIZATION ; POSITIVE PREDICTOR ; WOMEN ; FAILURES
英文摘要:

To identify whether biochemical pregnancy (BP) and spontaneous abortion (SA) cases have the same clinical characteristics in assisted reproductive therapy (ART), and to assess its predictive value for the subsequent cycles.

Retrospectively reviewed 12,174 cycles in the first in vitro fertilization and embryo transfer (IVF-ET) cycle from January 2009 to December 2012 of Peking University Third Hospital Reproductive Medical Center. Besides those patients who reached ongoing pregnancy stage, 7,598 cases were divided into three groups: group 1, lack of pregnancy (n = 6,651); group 2, BP (n = 520); and group 3, SA (n = 427). We compared the basic status of patients of the three groups, including ages, body mass index, basic hormone levels, controlled ovarian hyperstimulation protocols, amount of gonadotropin use, and endometrium thickness. The reproductive outcome of the next embryo transfer cycles of the three groups was analyzed.

520 patients ended as BP, and 427 patients ended as SA. The age, primary infertility proportion, body mass index, basic FSH level and basic E2 level were similar among groups. Endometrial thickness, controlled ovarian hyperstimulation protocol, Gn dosage, average oocyte retrieval and ET numbers were also similar. Multivariate analysis showed that only the age (P = 0.037, OR 1.060, 95 % CI 1.001-1.120) and endometrium thickness on hCG administration day (P = 0.029, OR 1.136, 95 % CI 1.013-1.275) may result in the differences between BP and SA groups. In the subsequent ET cycles, the total BP rate was 4.37 %, clinical pregnancy rate was 37.28 %, and miscarriage rate was 8.18 %. The clinical pregnancy rates were similar among groups. However, BP group still had the highest BP rate (P < 0.05, 7.97 vs. 4.01 % and 5.28 %), BP and SA group had higher miscarriage rate (P < 0.05, 11.76 % and 14.75 vs. 7.41 %).

BP and SA in first IVF cycles had negative predictive value for subsequent ART outcomes.

语种: 英语
WOS记录号: WOS:000355864000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53862
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Obstet & Gynecol, Reprod Med Ctr, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Rui,Yang, Shuo,Li, Rong,et al. Biochemical pregnancy and spontaneous abortion in first IVF cycles are negative predictors for subsequent cycles: an over 10,000 cases cohort study[J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS,2015,292(2):453-458.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Rui]'s Articles
[Yang, Shuo]'s Articles
[Li, Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Rui]‘s Articles
[Yang, Shuo]‘s Articles
[Li, Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace