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学科主题: 临床医学
题名:
Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease
作者: Cui, R.; Zhang, H.; Zhou, L.; Lu, J.; Xue, Y.; Wang, Y.; Yan, X.; Lin, L.; Lin, S.
关键词: 24-hour pH-impedance monitoring ; dilated intercellular space ; functional heartburn ; gastroesophageal reflux disease ; histopathology
刊名: DISEASES OF THE ESOPHAGUS
发表日期: 2015-08-01
DOI: 10.1111/dote.12256
卷: 28, 期:6, 页:530-537
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ESOPHAGEAL EPITHELIUM ; SQUAMOUS EPITHELIUM ; GERD ; EPIDEMIOLOGY ; MANAGEMENT ; IMPEDANCE ; SYMPTOMS
英文摘要:

The aim of this paper is to investigate the diagnostic value of histopathologic score and the dilated intercellular space (DIS) in patients with gastroesophageal reflux disease (GERD) and functional heartburn (FH). Participants with GERD symptoms including reflux esophagitis, non-erosive reflux disease (NERD), Barrett′s esophagus (BE), functional heartburn (FH), along with a control group with atypical GERD-like symptom (Sym-C), and asymptomatic healthy volunteers (H-C) were administered GERD questionnaire, and subjected to endoscopy and biopsies, as well as 24-hour pH-impedance monitoring. Biopsies were evaluated using standards from the 2011 Esohisto Project after Hematoxylin-Eosin staining. DIS was measured quantitatively under light microscopy. Among the total of 565 participants with qualified biopsy specimens, the mean DIS of the reflux esophagitis (RE) group was significantly wider compared with the other five groups. DIS in patients with GERD-like symptoms was significantly wider compared with the H-C. No significant differences were observed between NERD and FH. Results from 24-hour pH-impedance monitoring indicated that only the DIS of patients with acid reflux or the amount of acid reflux episodes in patients with DIS was significantly wider compared with patients with nonacid reflux or patients without DIS (P < 0.001). With DIS = 0.9m as the cutoff value, the sensitivity and specificity were 62.6% and 54.1%, respectively. Using the total histopathologic score > 3 as the diagnostic criterion, the sensitivity and specificity were 71.7% and 47.4%. DIS is closely associated with GERD and acid reflux. The diagnostic value of histological scores in lower esophagus in GERD is very similar to that of the quantitative measurement of DIS.

语种: 英语
项目资助者: National Key Clinical Department - Project of Digestive Diseases
WOS记录号: WOS:000360581700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53865
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China

Recommended Citation:
Cui, R.,Zhang, H.,Zhou, L.,et al. Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease[J]. DISEASES OF THE ESOPHAGUS,2015,28(6):530-537.
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