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学科主题基础医学
Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
Han, WL; Lou, YX; Tang, JM; Zhang, YM; Chen, YY; Li, Y; Gu, WF; Huang, JQ; Gui, LM; Tang, Y; Li, F; Song, QS; Di, CH; Wang, L; Shi, Q; Sun, RH; Xia, DL; Rui, M; Tang, J; Ma, DL
关键词interleukin 10 skeletal-muscle cells splicing suppression-subtractive hybridization
刊名BIOCHEMICAL JOURNAL
2001-07-01
357期:0页:127-135
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]CC-CHEMOKINE ; MESSENGER-RNAS ; FUNCTIONAL-CHARACTERIZATION ; SIGNAL PEPTIDES ; BETA-CHEMOKINE ; CHEMOATTRACTANT ; CELLS ; LYMPHOCYTES ; EXPRESSION ; PREDICTION
英文摘要

Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1 (CKLF1). The full-length cDNA of CKLF1 is 530 bp long and a single open reading frame encoding 99 amino acid residues. CKLF1 bears no significant similarity to any other known cytokine in its amino acid sequence, Expression of CKLF1 can be partly inhibited by interleukin 10 in PHA-stimulated U937 cells. Recombinant CKLF1 is a potent chemoattractant for neutrophils. monocytes and lymphocytes; moreover, it can stimulate the proliferation of murine skeletal muscle cells. These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle.

语种英语
WOS记录号WOS:000169783500015
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被引频次:88[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53868
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Histol Lab, Beijing 100083, Peoples R China
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Han, WL,Lou, YX,Tang, JM,et al. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity[J]. BIOCHEMICAL JOURNAL,2001,357(0):127-135.
APA Han, WL.,Lou, YX.,Tang, JM.,Zhang, YM.,Chen, YY.,...&Ma, DL.(2001).Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity.BIOCHEMICAL JOURNAL,357(0),127-135.
MLA Han, WL,et al."Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity".BIOCHEMICAL JOURNAL 357.0(2001):127-135.
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