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学科主题: 基础医学
题名:
Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
作者: Han, WL; Lou, YX; Tang, JM; Zhang, YM; Chen, YY; Li, Y; Gu, WF; Huang, JQ; Gui, LM; Tang, Y; Li, F; Song, QS; Di, CH; Wang, L; Shi, Q; Sun, RH; Xia, DL; Rui, M; Tang, J; Ma, DL
关键词: interleukin 10 ; skeletal-muscle cells ; splicing ; suppression-subtractive hybridization
刊名: BIOCHEMICAL JOURNAL
发表日期: 2001-07-01
卷: 357, 期:0, 页:127-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CC-CHEMOKINE ; MESSENGER-RNAS ; FUNCTIONAL-CHARACTERIZATION ; SIGNAL PEPTIDES ; BETA-CHEMOKINE ; CHEMOATTRACTANT ; CELLS ; LYMPHOCYTES ; EXPRESSION ; PREDICTION
英文摘要:

Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1 (CKLF1). The full-length cDNA of CKLF1 is 530 bp long and a single open reading frame encoding 99 amino acid residues. CKLF1 bears no significant similarity to any other known cytokine in its amino acid sequence, Expression of CKLF1 can be partly inhibited by interleukin 10 in PHA-stimulated U937 cells. Recombinant CKLF1 is a potent chemoattractant for neutrophils. monocytes and lymphocytes; moreover, it can stimulate the proliferation of murine skeletal muscle cells. These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle.

语种: 英语
WOS记录号: WOS:000169783500015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53868
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Histol Lab, Beijing 100083, Peoples R China

Recommended Citation:
Han, WL,Lou, YX,Tang, JM,et al. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity[J]. BIOCHEMICAL JOURNAL,2001,357(0):127-135.
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