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学科主题: 基础医学
题名:
Bacteria-mediated in vivo delivery of quantum dots into solid tumor
作者: Liu, Ying1; Zhou, Mei2; Luo, Dan1; Wang, Lijun1; Hong, Yuankai1; Yang, Yepeng2; Sha, Yinlin1,3
关键词: Quantum dots ; Bifidobacterium bifidum ; Electroporation ; In vivo imaging
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2012-09-07
DOI: 10.1016/j.bbrc.2012.07.150
卷: 425, 期:4, 页:769-774
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CANCER GENE-THERAPY ; SELECTIVE LOCALIZATION ; NANOCRYSTALS ; SYSTEM ; GROWTH ; MICROENVIRONMENT ; STABILITY ; MICE
英文摘要:

Semiconductor nanocrystals, so-called quantum dots (QDs), promise potential application in bioimaging and diagnosis in vitro and in vivo owing to their high-quality photoluminescence and excellent photostability as well as size-tunable spectra. Here, we describe a biocompatible, comparatively safe bacteria-based system that can deliver QDs specifically into solid tumor of living animals. In our strategy, anaerobic bacterium Bifidobacterium bifidum (B. bifidum) that colonizes selectively in hypoxic regions of animal body was successfully used as a vehicle to load with QDs and transported into the deep tissue of solid tumors. The internalization of lipid-encapsuled QDs into B. bifidum was conveniently carried by electroporation. To improve the efficacy and specificity of tumor targeting, the QDs-carrying bacterium surface was further conjugated with folic acids (FAs) that can bind to the folic acid receptor overexpressed tumor cells. This new approach opens a pathway for delivering different types of functional cargos such as nanoparticles and drugs into solid tumor of live animals for imaging, diagnosis and therapy. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 20973008
项目资助者: NSFC
WOS记录号: WOS:000309017700013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53870
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Biomed X Ctr, Beijing 100091, Peoples R China
2.Peking Univ, Single Mol & Nanobiol Lab, Dept Biophys, Sch Basic Med Sci, Beijing 100091, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Beijing 100091, Peoples R China

Recommended Citation:
Liu, Ying,Zhou, Mei,Luo, Dan,et al. Bacteria-mediated in vivo delivery of quantum dots into solid tumor[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,425(4):769-774.
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