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学科主题基础医学
Bacteria-mediated in vivo delivery of quantum dots into solid tumor
Liu, Ying1; Zhou, Mei2; Luo, Dan1; Wang, Lijun1; Hong, Yuankai1; Yang, Yepeng2; Sha, Yinlin1,3
关键词Quantum dots Bifidobacterium bifidum Electroporation In vivo imaging
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2012-09-07
DOI10.1016/j.bbrc.2012.07.150
425期:4页:769-774
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CANCER GENE-THERAPY ; SELECTIVE LOCALIZATION ; NANOCRYSTALS ; SYSTEM ; GROWTH ; MICROENVIRONMENT ; STABILITY ; MICE
英文摘要

Semiconductor nanocrystals, so-called quantum dots (QDs), promise potential application in bioimaging and diagnosis in vitro and in vivo owing to their high-quality photoluminescence and excellent photostability as well as size-tunable spectra. Here, we describe a biocompatible, comparatively safe bacteria-based system that can deliver QDs specifically into solid tumor of living animals. In our strategy, anaerobic bacterium Bifidobacterium bifidum (B. bifidum) that colonizes selectively in hypoxic regions of animal body was successfully used as a vehicle to load with QDs and transported into the deep tissue of solid tumors. The internalization of lipid-encapsuled QDs into B. bifidum was conveniently carried by electroporation. To improve the efficacy and specificity of tumor targeting, the QDs-carrying bacterium surface was further conjugated with folic acids (FAs) that can bind to the folic acid receptor overexpressed tumor cells. This new approach opens a pathway for delivering different types of functional cargos such as nanoparticles and drugs into solid tumor of live animals for imaging, diagnosis and therapy. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000309017700013
项目编号20973008
资助机构NSFC
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53870
专题北京大学基础医学院_生物物理学系
北京大学基础医学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Biomed X Ctr, Beijing 100091, Peoples R China
2.Peking Univ, Single Mol & Nanobiol Lab, Dept Biophys, Sch Basic Med Sci, Beijing 100091, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Beijing 100091, Peoples R China
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GB/T 7714
Liu, Ying,Zhou, Mei,Luo, Dan,et al. Bacteria-mediated in vivo delivery of quantum dots into solid tumor[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,425(4):769-774.
APA Liu, Ying.,Zhou, Mei.,Luo, Dan.,Wang, Lijun.,Hong, Yuankai.,...&Sha, Yinlin.(2012).Bacteria-mediated in vivo delivery of quantum dots into solid tumor.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,425(4),769-774.
MLA Liu, Ying,et al."Bacteria-mediated in vivo delivery of quantum dots into solid tumor".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 425.4(2012):769-774.
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