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学科主题: 临床医学
题名:
Developmental changes in the geometry, function and responsiveness of the mouse heart to beta-adrenergic stimulation as determined by high-resolution echocardiography
作者: Xiao, Han1,2; Zhang, You-Yi1,2; Du, Xiao-Jun3,4; Lu, Zhi-Zhen1,2
关键词: beta-adrenoceptor activation ; cardiac development ; cardiac physiology ; echocardiography
刊名: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
发表日期: 2010-08-01
DOI: 10.1111/j.1440-1681.2010.05399.x
卷: 37, 期:8, 页:826-832
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: ADENYLATE-CYCLASE ; CARDIAC-FUNCTION ; RAT ; MICE ; DISEASE ; ADULT ; MECHANISMS ; PATTERNS ; MASS
英文摘要:

P>1. The mouse is the preferred species for gene targeting as a tool for research into the heart and heart development. The developmental features of the geometry and function of the heart in young mice are not well defined and cardiac functional responses following stimulation of beta-adrenoceptors have not been investigated.

2. Using the VisualSonic (Toronto, ON, Canada) high-resolution ultrasound system, we investigated male C57BL/6 mice at 0.5-18 weeks of age. Echocardiography was performed at baseline and repeated after administration of the beta-adrenoceptor agonist isoproterenol (4 mu g/kg).

3. The geometry of the left ventricle became mature 2 weeks after birth. A significant decline in left ventricular contractile function occurred at 2-3 weeks of age.

4. Inotropic and chronotropic responses to isoproterenol were significantly weaker in mice at a weaning age < 2 weeks compared with adult mice (heart rate increment 3 +/- 3% vs 32 +/- 4%, respectively; fractional shortening increment 19 +/- 5% vs 78 +/- 8%, respectively; P < 0.001).

5. In conclusion, significant changes occur in mice from birth until weaning with respect to the topography, function and beta-adrenoceptor responsiveness of the heart. The results of the present study provide a reference point for future studies in genotyping cardiac function during the postnatal phase in genetically engineered mice.

语种: 英语
所属项目编号: 2006CB503806 ; 30910103902 ; 307001
项目资助者: People&prime ; s Republic of China ; National Natural Science Foundation of China (NSFC) of International Cooperation and Exchanges ; Chinese Ministry of Education
WOS记录号: WOS:000280457100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53872
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Monash Univ, Alfred Med Sch, Melbourne, Vic 3004, Australia
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
4.Monash Univ, Baker IDI Heart Diabet Inst, Melbourne, Vic 3004, Australia

Recommended Citation:
Xiao, Han,Zhang, You-Yi,Du, Xiao-Jun,et al. Developmental changes in the geometry, function and responsiveness of the mouse heart to beta-adrenergic stimulation as determined by high-resolution echocardiography[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2010,37(8):826-832.
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