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学科主题基础医学
Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection
Shen, Tao1; Chen, Xiangmei1; Chen, Yu2; Xu, Qiang1; Lu, Fengmin1; Liu, Shuang2
关键词hepatitis C virus plasmacytoid dendritic cells myeloid dendritic cells PD-L1
刊名JOURNAL OF MEDICAL VIROLOGY
2010-07-01
DOI10.1002/jmv.21809
82期:7页:1152-1159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者China National Science and Technology ; Peking University Health Science Center ; China National Science and Technology ; Peking University Health Science Center
研究领域[WOS]Virology
关键词[WOS]HEPATITIS-C-VIRUS ; IMMUNE-RESPONSES ; T-CELLS ; HIV-INFECTION ; UP-REGULATION ; B7 FAMILY ; DYSFUNCTION ; ACTIVATION ; EXHAUSTION ; REPLICATION
英文摘要

Impaired hepatitis C virus (HCV)-specific T cell immunity was associated with the persistence of HCV infection. Dysfunction of dentritic cells (DCs) was believed to be involved in T cell exhaustion, but the mechanisms were rarely understood. In this study, surface costimulatory marker (CD83, CD86, and CD40), coinhibitory marker (PD-L1) expression and allostimulatory capacity of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) were evaluated in HCV-infected patients. Results showed that the expression of both costimulatory and coinhibitory markers was increased in HCV-infected patients compared with healthy controls. PD-L1/CD86 ratio was increased and positively correlated with PD-L1 expression on DCs in HCV-infected patients. Allostimulatory capacity of DCs was impaired and inversely correlated with PD-L1 expression and PD-L1/CD86 ratio. These findings suggested that the effect of inhibitory marker PD-L1 overwhelmed the effect of costimulatory markers and down regulated DC-T activation in HCV-infected patients. The results will be helpful to understand the mechanism of dysfunction of DCs in HCV infection and shed light on the DC-based immunotherapeutic strategy. J. Med. Viral. 82:1152-1159, 2010. (C) 2010 Wiley-Liss, Inc.

语种英语
所属项目编号2008ZX10002-013 ; BMU20090529-123
资助者China National Science and Technology ; Peking University Health Science Center ; China National Science and Technology ; Peking University Health Science Center
WOS记录号WOS:000278173400008
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53874
专题北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Shen, Tao,Chen, Xiangmei,Chen, Yu,et al. Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection[J]. JOURNAL OF MEDICAL VIROLOGY,2010,82(7):1152-1159.
APA Shen, Tao,Chen, Xiangmei,Chen, Yu,Xu, Qiang,Lu, Fengmin,&Liu, Shuang.(2010).Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection.JOURNAL OF MEDICAL VIROLOGY,82(7),1152-1159.
MLA Shen, Tao,et al."Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection".JOURNAL OF MEDICAL VIROLOGY 82.7(2010):1152-1159.
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