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学科主题: 基础医学
题名:
Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection
作者: Shen, Tao1; Chen, Xiangmei1; Chen, Yu2; Xu, Qiang1; Lu, Fengmin1; Liu, Shuang2
关键词: hepatitis C virus ; plasmacytoid dendritic cells ; myeloid dendritic cells ; PD-L1
刊名: JOURNAL OF MEDICAL VIROLOGY
发表日期: 2010-07-01
DOI: 10.1002/jmv.21809
卷: 82, 期:7, 页:1152-1159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-C-VIRUS ; IMMUNE-RESPONSES ; T-CELLS ; HIV-INFECTION ; UP-REGULATION ; B7 FAMILY ; DYSFUNCTION ; ACTIVATION ; EXHAUSTION ; REPLICATION
英文摘要:

Impaired hepatitis C virus (HCV)-specific T cell immunity was associated with the persistence of HCV infection. Dysfunction of dentritic cells (DCs) was believed to be involved in T cell exhaustion, but the mechanisms were rarely understood. In this study, surface costimulatory marker (CD83, CD86, and CD40), coinhibitory marker (PD-L1) expression and allostimulatory capacity of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) were evaluated in HCV-infected patients. Results showed that the expression of both costimulatory and coinhibitory markers was increased in HCV-infected patients compared with healthy controls. PD-L1/CD86 ratio was increased and positively correlated with PD-L1 expression on DCs in HCV-infected patients. Allostimulatory capacity of DCs was impaired and inversely correlated with PD-L1 expression and PD-L1/CD86 ratio. These findings suggested that the effect of inhibitory marker PD-L1 overwhelmed the effect of costimulatory markers and down regulated DC-T activation in HCV-infected patients. The results will be helpful to understand the mechanism of dysfunction of DCs in HCV infection and shed light on the DC-based immunotherapeutic strategy. J. Med. Viral. 82:1152-1159, 2010. (C) 2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 2008ZX10002-013 ; BMU20090529-123
项目资助者: China National Science and Technology ; Peking University Health Science Center
WOS记录号: WOS:000278173400008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53874
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China

Recommended Citation:
Shen, Tao,Chen, Xiangmei,Chen, Yu,et al. Increased PD-L1 Expression and PD-L1/CD86 Ratio on Dendritic Cells Were Associated With Impaired Dendritic Cells Function in HCV Infection[J]. JOURNAL OF MEDICAL VIROLOGY,2010,82(7):1152-1159.
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