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学科主题: 药学
题名:
Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats
作者: Mao, Xueqin2; Zhang, Ling3; Xia, Qing1; Sun, Zhaofeng3; Zhao, Xiaomin3; Cai, Hongxin3; Yang, Xiaoda1; Xia, Zuoli2; Tang, Yujing3
关键词: chickpea sprout ; enriching ; streptozotocin-induced diabetes ; rats ; SOV
刊名: BIOMETALS
发表日期: 2008-10-01
DOI: 10.1007/s10534-008-9142-y
卷: 21, 期:5, 页:563-570
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CICER-ARIETINUM ; INSULIN ; VANADATE ; COMPLICATIONS ; CYTOTOXICITY ; PERMEABILITY ; TOXICITY ; TEA
英文摘要:

Vanadium compounds have been recognized for their hypoglycemic effects; however, potential short and long-term vanadium toxicity has slowed the acceptance for therapeutic use. In the present work, three batches of vanadium-enriched chickpea sprout (VCS) were prepared by incubating chickpea seeds in presence of 200, 100, and 50 mu g/ml of sodium orthovanadate (SOV). The effects of oral administration of chickpea sprout (CS) and VCS food for 8 weeks on streptozotocin-induced (STZ) diabetic rats were investigated. Both CS and VCS food was found to ameliorate some hyperglycemic symptoms of the diabetic rats, i.e. improve lipid metabolism, decrease blood glucose level, prevent body weight loss, and reduce impairment of diabetic related spatial learning and memory. Serum insulin was substantially elevated in treated diabetic rats, which is probably one important reason for the hypoglycemic effect. Compared with CS alone, VCS100 food exhibited remarkably enhanced effectiveness in alleviating diabetes induced hyperglycemia and memory loss. Moreover, vanadium-enriched chickpeas appeared to abolish the vanadium induced toxicity associated with administration of this metal for diabetes during the 8-week study period. This study suggested further work of the vanadium speciation in CS and novel hypoglycemic mechanism for the antidiabetic activity of vanadium agents. Vanadium containing (VCS) food could be a dietary supplement for the diabetic status.

语种: 英语
所属项目编号: Z0004105040311
项目资助者: 985 program ; Committee of Science and Technology of Beijing
WOS记录号: WOS:000258897100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53875
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem,Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Shandong, Peoples R China
3.Taishan Med Univ, Res Inst Basal Med, Tai An 271000, Shandong, Peoples R China

Recommended Citation:
Mao, Xueqin,Zhang, Ling,Xia, Qing,et al. Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats[J]. BIOMETALS,2008,21(5):563-570.
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