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Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats
Mao, Xueqin2; Zhang, Ling3; Xia, Qing1; Sun, Zhaofeng3; Zhao, Xiaomin3; Cai, Hongxin3; Yang, Xiaoda1; Xia, Zuoli2; Tang, Yujing3
关键词Chickpea Sprout Enriching Streptozotocin-induced Diabetes Rats Sov
刊名BIOMETALS
2008-10-01
DOI10.1007/s10534-008-9142-y
21期:5页:563-570
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]CICER-ARIETINUM ; INSULIN ; VANADATE ; COMPLICATIONS ; CYTOTOXICITY ; PERMEABILITY ; TOXICITY ; TEA
英文摘要

Vanadium compounds have been recognized for their hypoglycemic effects; however, potential short and long-term vanadium toxicity has slowed the acceptance for therapeutic use. In the present work, three batches of vanadium-enriched chickpea sprout (VCS) were prepared by incubating chickpea seeds in presence of 200, 100, and 50 mu g/ml of sodium orthovanadate (SOV). The effects of oral administration of chickpea sprout (CS) and VCS food for 8 weeks on streptozotocin-induced (STZ) diabetic rats were investigated. Both CS and VCS food was found to ameliorate some hyperglycemic symptoms of the diabetic rats, i.e. improve lipid metabolism, decrease blood glucose level, prevent body weight loss, and reduce impairment of diabetic related spatial learning and memory. Serum insulin was substantially elevated in treated diabetic rats, which is probably one important reason for the hypoglycemic effect. Compared with CS alone, VCS100 food exhibited remarkably enhanced effectiveness in alleviating diabetes induced hyperglycemia and memory loss. Moreover, vanadium-enriched chickpeas appeared to abolish the vanadium induced toxicity associated with administration of this metal for diabetes during the 8-week study period. This study suggested further work of the vanadium speciation in CS and novel hypoglycemic mechanism for the antidiabetic activity of vanadium agents. Vanadium containing (VCS) food could be a dietary supplement for the diabetic status.

语种英语
WOS记录号WOS:000258897100006
项目编号Z0004105040311
资助机构985 program ; Committee of Science and Technology of Beijing
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53875
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem,Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Shandong, Peoples R China
3.Taishan Med Univ, Res Inst Basal Med, Tai An 271000, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Mao, Xueqin,Zhang, Ling,Xia, Qing,et al. Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats[J]. BIOMETALS,2008,21(5):563-570.
APA Mao, Xueqin.,Zhang, Ling.,Xia, Qing.,Sun, Zhaofeng.,Zhao, Xiaomin.,...&Tang, Yujing.(2008).Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats.BIOMETALS,21(5),563-570.
MLA Mao, Xueqin,et al."Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats".BIOMETALS 21.5(2008):563-570.
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