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PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation
Huang, Shengquan1,2; Liao, Qianjin3; Li, Longkun1,2; Xin, Dianqi4
关键词Pituitary Tumor-transforming Gene 1 Smad3 Prostate Cancer
刊名TUMOR BIOLOGY
2014-07-01
DOI10.1007/s13277-014-1818-z
35期:7页:6265-6270
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Third Military Medical University ; Third Military Medical University
研究领域[WOS]Oncology
关键词[WOS]TUMOR-TRANSFORMING GENE ; TGF-BETA ; OVARIAN-CANCER ; CARCINOMA ; OVEREXPRESSION ; EXPRESSION ; THERAPY ; HPTTG
英文摘要

Increased expression of pituitary tumor-transforming gene 1 (PTTG1) occurs during mitosis-related sister chromatid segregation, and characterizes various tumor cells, including prostate cancer. Whereas the mechanism remains unclarified. Here, the PTTG1 levels in a prostate cancer cell line, PC3, were modulated by the expression of PTTG1 transgene or shRNA, showing that the PTTG1 levels affected the proliferation of prostate cancer cells, in vitro and in vivo. Moreover, a significant decrease in mothers against decapentaplegic homolog 3 (SMAD3), a key component of transforming growth factor beta (TGF beta) signaling pathway, was induced by PTTG1 overexpression. Since SMAD3 is a ubiquitous cell-cycle inhibitor, our data suggest that PTTG1 may promote the proliferation of prostate cancer cells by inhibiting SMAD3-mediated TGF beta signaling. To identify a causal link, we expressed SMAD3 in PTTG1-overexpressing PC3 cells and found that SMAD3 expression inhibited the augmented cancer cell proliferation by PTTG1overexpression. Furthermore, SMAD3 inhibition by short hairpin RNA (ShRNA) completely rescued the cancer cell proliferation in PTTG1 ShRNA-treated PC3 cells. Taken together, our data suggest that PTTG1 promotes the proliferation of prostate cancer cells via the inhibition of SMAD3. SMAD3 thus appears to be a novel therapeutic target for suppressing the growth of prostate cancer.

语种英语
资助者Third Military Medical University ; Third Military Medical University
WOS记录号WOS:000339736300017
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53876
专题北京大学第一临床医学院_泌尿外科
作者单位1.Third Mil Med Univ, Dept Urol, Chongqing 40037, Peoples R China
2.Third Mil Med Univ, Ctr Nephrol, Xinqiao Hosp, Chongqing 40037, Peoples R China
3.Xinqiao Community Hlth Serv Ctr Shapingba Dist, Chongqing, Peoples R China
4.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
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GB/T 7714
Huang, Shengquan,Liao, Qianjin,Li, Longkun,et al. PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation[J]. TUMOR BIOLOGY,2014,35(7):6265-6270.
APA Huang, Shengquan,Liao, Qianjin,Li, Longkun,&Xin, Dianqi.(2014).PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation.TUMOR BIOLOGY,35(7),6265-6270.
MLA Huang, Shengquan,et al."PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation".TUMOR BIOLOGY 35.7(2014):6265-6270.
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